Table 7 Variables associated with and independent predictors of low adiponectin serum levels (<6 μg/ml) in 261 CHC patients
Adiponectin | Low (n = 72) | High (n = 189) | p | OR * (95% c.i.) | p * |
|---|---|---|---|---|---|
Steatosis present | 59 (82) | 120 (63) | 0.004 | 3.85 (1.78-8.91) | 0.0005 |
Age (years) | 51±14 | 61±13 | <0.0001 | 0.95 (0.92-0.97) | <0.0001 |
Sex (F) | 10 (14) | 100 (53) | <0.0001 | 0.18 (0.08-0.38) | <0.0001 |
HDL (mg/dl) | 42±11 | 53±17 | <0.0001 | - | - |
Triglycerides (mg/dl) | 121±71 | 98±38 | 0.012 | - | - |
Cirrhosis | 15 (21) | 65 (34) | 0.036 | 0.65 (0.30-1.40) | 0.277 |
Viral genotype 4 | 11 (15) | 8 (4) | 0.0055 | 1.68 (0.55-5.70) | 0.456 |
ADIPOQ | |||||
rs2241766TT and rs1501299T+ | 26 (36) | 92 (49) | 0.068 | 0.74 (0.39-1.40) | 0.355 |
rs2241766G + or rs1501299GG | 46 (64) | 97 (51) | reference | ||
PNPLA3 rs738409 | |||||
CC (148 I/I) | 34 (47) | 99 (52) | 0.73 | 1.15 (0.71-2.80) | 0.600 |
CG (148 I/M) | 30 (42) | 73 (39) | |||
GG (148 M/M) | 8 (11) | 17 (9) |