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Table 3 Independent predictors of steatosis grade 2–3, NASH, and of fibrosis at logistic regression analysis in 115 consecutive biopsied patients with NAFLD with available DNA and serum samples at the time of liver biopsy

From: The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls

Variables

Steatosis grade 2–3 vs. 1

NASH vs. simple steatosis

Fibrosis vs. no fibrosis

 

OR (95% c.i.)

p value

OR (95% c.i.)

p value

OR (95% c.i.)

p value

Age (years)

1.04 (0.99-1.09)

0.094

1.01 (0.96-1.06)

0.598

1.06 (1.01-1.10)

0.020

Sex (F)

1.31 (0.40-4.2)

0.656

0.88 (0.27-2.89)

0.834

0.55 (0.18-1.65)

0.282

BMI (Kg/m2)

1.22 (1.04-1.44)

0.014

1.32 (1.11-1.56)

0.002

1.13 (0.99-1.30)

0.079

ALT (IU/ml)

1.02 (1.01-1.03)

0.007

1.01 (1.00-1.02)

0.028

1.01 (1.00-1.02)

0.028

Glucose (mg/dl)

0.99 (0.98-1.01)

0.217

1.03 (1.00-1.05)

0.061

1.02 (0.99-1.04)

0.214

Insulin (IU/ml)

1.01 (0.97-1.06)

0.618

0.99 (0.94-1.04)

0.654

0.98 (0.94-1.03)

0.473

FFAs (mmol/l)

1.00 (0.98-1.01)

0.453

1.00 (0.99-1.01)

0.671

1.00 (0.99-1.01)

0.934

Adiponectin (μg/ml)

0.83 (0.72-0.96)

0.012

0.86 (0.75-0.98)

0.025

0.84 (0.74-0.95)

0.006

  1. OR odds ratio, c.i. confidence interval, BMI body mass index, FFAs free fatty acids; the presence of NASH and fibrosis were defined according to the NASH clinical research network definition [31].