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Table 2 Distribution of autoimmune diseases in PBC patients, controls and FDR

From: Primary Biliary Cirrhosis in a genetically homogeneous population: Disease associations and familial occurrence rates

Autoimmune disease PBC patients (N = 111) Controls (N = 149) PBC vs controls p-value, OR (95% C.I.) FDRs (N = 115) FDR vs controls p-value OR (95%C.I.)
RA 4.5% (5/111) 0.7% (1/149) 0.087, 7 (0.79-56.64) 3.5% (4/115) 0.171, 5.32 (0.59-47.62)
S.L.E 3.6% (4/111) 1.3% (2/149) 0.407, 2.75 (0.49-15.38) 1.7% (2/115) 1, 1.3 (0.18-9.35)
Scleroderma 1.8% (2/111) 0% (0/149) 0.181, 1.02 (0.99-1.04) 0.9% (1/115) 0.436, 1 (0.99-1.03)
Sarcoidosis 2.7% (3/111) 0.7% (1/149) 0.316, 4.11 (0.42-40) 0.9% (1/115) 1, 1.3 (0.08-20.83)
Sjögren Syndrome 5.4% (6/111) 0.7% (1/149) 0.044*, 8.47 (1–71.43) 0% (0/115) 1, 0.99 (0.98-1.01)
Raynaud 6.3% (7/111) 0.7% (1/149) 0.023*, 10 (1.21-83.33) 2.6% (3/115) 0.321, 3.97 (0.41-38.46)
Eczema 3.6% (4/111) 2.7% (4/149) 0.727, 1.35 (0.33-5.55) 2.6% (3/115) 1, 0.97 (0.21-4.42)
Psoriasis 1.8% (2/111) 1.3% (2/149) 1, 1.35 (0.19-9.71) 3.5% (4/115) 0.409, 2.65 (0.48-14.71)
IBD 1.8% (2/111) 0.7% (1/149) 0.577, 2.72 (0.24-30.3) 0% (0/115) 1, 0.99 (0.98-1.01)
Hashimoto 18% (20/111) 6% (9/149) 0.003*, 3.41 (1.49-7.81) 13.9% (16/115) 0.035*, 2.51 (1,07-5,92)
At least another autoimmune disease 36.9% (41/111) 13.4% (20/149) <0.0001*, 3.77 (2.06-6.94) 26.1% (30/115) 0.011*, 2.28 (1.21-4.27)
  1. OR = Odds Ratio, *Statistically significant.