Table 2 Distribution of autoimmune diseases in PBC patients, controls and FDR
Autoimmune disease | PBC patients (N = 111) | Controls (N = 149) | PBC vs controls p-value, OR (95% C.I.) | FDRs (N = 115) | FDR vs controls p-value OR (95%C.I.) |
|---|---|---|---|---|---|
RA | 4.5% (5/111) | 0.7% (1/149) | 0.087, 7 (0.79-56.64) | 3.5% (4/115) | 0.171, 5.32 (0.59-47.62) |
S.L.E | 3.6% (4/111) | 1.3% (2/149) | 0.407, 2.75 (0.49-15.38) | 1.7% (2/115) | 1, 1.3 (0.18-9.35) |
Scleroderma | 1.8% (2/111) | 0% (0/149) | 0.181, 1.02 (0.99-1.04) | 0.9% (1/115) | 0.436, 1 (0.99-1.03) |
Sarcoidosis | 2.7% (3/111) | 0.7% (1/149) | 0.316, 4.11 (0.42-40) | 0.9% (1/115) | 1, 1.3 (0.08-20.83) |
Sjögren Syndrome | 5.4% (6/111) | 0.7% (1/149) | 0.044*, 8.47 (1–71.43) | 0% (0/115) | 1, 0.99 (0.98-1.01) |
Raynaud | 6.3% (7/111) | 0.7% (1/149) | 0.023*, 10 (1.21-83.33) | 2.6% (3/115) | 0.321, 3.97 (0.41-38.46) |
Eczema | 3.6% (4/111) | 2.7% (4/149) | 0.727, 1.35 (0.33-5.55) | 2.6% (3/115) | 1, 0.97 (0.21-4.42) |
Psoriasis | 1.8% (2/111) | 1.3% (2/149) | 1, 1.35 (0.19-9.71) | 3.5% (4/115) | 0.409, 2.65 (0.48-14.71) |
IBD | 1.8% (2/111) | 0.7% (1/149) | 0.577, 2.72 (0.24-30.3) | 0% (0/115) | 1, 0.99 (0.98-1.01) |
Hashimoto | 18% (20/111) | 6% (9/149) | 0.003*, 3.41 (1.49-7.81) | 13.9% (16/115) | 0.035*, 2.51 (1,07-5,92) |
At least another autoimmune disease | 36.9% (41/111) | 13.4% (20/149) | <0.0001*, 3.77 (2.06-6.94) | 26.1% (30/115) | 0.011*, 2.28 (1.21-4.27) |