From: Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis
Group | Cancer | Normal | Sum | M-H pooled OR | D+L pooled OR | Heterogeneity | Ï„2 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | M+ | N | M+ | N |  | OR (95%CI) | z | p | OR(95%CI) | z | P | χ2 | I2 (%) | P |  |
Total | 475 | 928 | 159 | 812 | 1740 | 5.52(4.30, 7.10) | 13.3 | < 0.0001 | 5.63(3.15,10.07) | 5.82 | < 0.0001 | 57.91 | 74.1 | < 0.0001 | 0.94 |
Tissue subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
Autologous tissue | 362 | 739 | 117 | 728 | 1467 | 7.15(5.36, 9.53) | 13.4 | < 0.0001 | 6.42(4.07,10.11) | 8 | < 0.0001 | 24.12 | 50.02 | 0.02 | 0.32 |
Heterogeneous tissue | 113 | 189 | 42 | 84 | 273 | 5.52(4.30, 7.10) | 2.22 | 0.026 | 4.44(0.35,56.70) | 1.15 | 0.251 | 18.69 | 89.3 | < 0.0001 | 4.21 |
Origin subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
Japan | 234 | 441 | 89 | 332 | 773 | 3.20(2.30, 4.47) | 6.86 | < 0.0001 | 3.20(1.60,6.39) | 3.29 | 0.001 | 25.03 | 72 | 0.001 | 0.7 |
Euro-America | 65 | 85 | 45 | 85 | 170 | 8.12(2.76, 23.88) | 3.8 | < 0.0001 | 5.15(0.23,113.17) | 1.04 | 0.299 | 5.95 | 83.2 | 0.015 | 4.14 |
China | 132 | 249 | 14 | 253 | 502 | 18.44(10.30, 33.03) | 9.8 | < 0.0001 | 26.19(8.04,85.33) | 5.42 | < 0.0001 | 5.82 | 48.4 | 0.121 | 0.66 |
Korea | 44 | 153 | 11 | 142 | 295 | 5.10(2.48, 10.47) | 4.42 | < 0.0001 | 4.96(2.14,11.47) | 3.74 | < 0.0001 | 1.18 | 15.5 | 0.277 | 0.07 |
Age subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
age < 60 | 46 | 114 | 4 | 133 | 247 | 15.25(5.33, 43.61) | 5.08 | < 0.0001 | 15.00(5.21,43.15) | 5.02 | < 0.0001 | 0.6 | < 0.001 | 0.437 | < 0.001 |
60≤age < 65 | 276 | 539 | 83 | 465 | 1004 | 7.41(5.16, 10.62) | 10.9 | < 0.0001 | 6.31(3.19,12.46) | 5.3 | < 0.0001 | 18.88 | 62.9 | 0.009 | 0.54 |
age≥65 | 153 | 245 | 72 | 214 | 459 | 2.93(1.98, 4.32) | 5.39 | < 0.0001 | 3.75(1.29,10.89) | 2.43 | 0.015 | 25.18 | 80.1 | < 0.0001 | 1.31 |