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Table 2 Subgroup analysis

From: Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis

Group Cancer Normal Sum M-H pooled OR D+L pooled OR Heterogeneity τ2
  M+ N M+ N   OR (95%CI) z p OR(95%CI) z P χ2 I2 (%) P  
Total 475 928 159 812 1740 5.52(4.30, 7.10) 13.3 < 0.0001 5.63(3.15,10.07) 5.82 < 0.0001 57.91 74.1 < 0.0001 0.94
Tissue subgroup               
Autologous tissue 362 739 117 728 1467 7.15(5.36, 9.53) 13.4 < 0.0001 6.42(4.07,10.11) 8 < 0.0001 24.12 50.02 0.02 0.32
Heterogeneous tissue 113 189 42 84 273 5.52(4.30, 7.10) 2.22 0.026 4.44(0.35,56.70) 1.15 0.251 18.69 89.3 < 0.0001 4.21
Origin subgroup               
Japan 234 441 89 332 773 3.20(2.30, 4.47) 6.86 < 0.0001 3.20(1.60,6.39) 3.29 0.001 25.03 72 0.001 0.7
Euro-America 65 85 45 85 170 8.12(2.76, 23.88) 3.8 < 0.0001 5.15(0.23,113.17) 1.04 0.299 5.95 83.2 0.015 4.14
China 132 249 14 253 502 18.44(10.30, 33.03) 9.8 < 0.0001 26.19(8.04,85.33) 5.42 < 0.0001 5.82 48.4 0.121 0.66
Korea 44 153 11 142 295 5.10(2.48, 10.47) 4.42 < 0.0001 4.96(2.14,11.47) 3.74 < 0.0001 1.18 15.5 0.277 0.07
Age subgroup               
age < 60 46 114 4 133 247 15.25(5.33, 43.61) 5.08 < 0.0001 15.00(5.21,43.15) 5.02 < 0.0001 0.6 < 0.001 0.437 < 0.001
60≤age < 65 276 539 83 465 1004 7.41(5.16, 10.62) 10.9 < 0.0001 6.31(3.19,12.46) 5.3 < 0.0001 18.88 62.9 0.009 0.54
age≥65 153 245 72 214 459 2.93(1.98, 4.32) 5.39 < 0.0001 3.75(1.29,10.89) 2.43 0.015 25.18 80.1 < 0.0001 1.31
  1. M+: The number of tissues with methylation; N: Number of the total observations.