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Table 2 Indirect Serum Markers of Liver Fibrosis.

From: Non-Invasive markers for hepatic fibrosis

Indices

Individual components

Sensitivity (%)

Specificity (%)

AST/ALT ratio

Aspartate aminotransferase,

Alanine aminotransferase

53

100

PGA

Protrombin index, GGT, apolipoprotein A1

91

81

APRI

AST/platelet count

89

75

FibroSpect II

HA, TIMP-1, α2-macroglobulin

83.5

66.7

FibroTest/FibroSure

γ2 macroglobulin, γ2 globulin, γ globulin, apolipoprotein A1, GGT, total bilirubin

75

85

FibroIndex

Platelet count, AST, GGT

78

74

FibroMeter

Platelet count, γ2 macroglobulin, AST, age, prothrombin index, HA, blood urea nitrogen

81

84

Forns

Age, platelet count, GGT, cholestered levels

94

51

Hepascore

Age, gender, bilirubin, GGT, HA, γ2-macroglobulin

63

89

FIB-4

Platelet count, ALT, AST, platelet count, age

70

74

SHASTA Index

HA, AST, albumin

100

52

Simple test

age, hyperglycemia, BMI, platelet count, albumin, AST/ALT

78

58

OELF/ELF

age, HA, N-terminal propeptide of type III collagen, TIMP-1

90

41

  1. GGT: γ glutamyl transferase, HA: hyaluronic acid, TIMP-1: Tissue inhibitors of matrix metalloproteinase- 1, ALT: Alanine aminotransferase, AST: Aspartate aminotransferase