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Table 3 Myeloperoxidase (MPO) activity in the jejunum segment from inducible nitric oxide synthase knock-out mice (iNOS-/-) and C57BL/6 wild-type animals (iNOS+/+) submitted to intestinal mucositis

From: Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents

  iNOS+/+/control iNOS+/+/MTX iNOS-/-control iNOS-/-/MTX
Mean ± Std. error 0.056 ± 0.01 8.45 ± 0.60 * 0.035 ± 0.02 0.056 ± 0.001
  1. Intestinal mucositis was induced by subcutaneous administration of MTX. After sacrifice, on the 5th day, a sample of the jejunum segment was harvested for MPO activity assay. *p < 0.05 represents statistical differences compared to iNOS+/+/control group. The number of animals in each group was at least four. Data were analyzed by using analysis of variance (ANOVA) and Bonferroni tests.