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Table 2 Effect of aminoguanidina (AG) and L-NAME on microscopic findings of duodenum, jejunum and ileum of animals submitted to methotrexate (MTX)-induced intestinal mucositis, observed on 5th day

From: Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents

  Duodenum Jejunum Ileum
Control 0 (0-0) 0 (0-0) 0 (0-0)
MTX 3 (3-3)* 3 (3-3)* 3 (3-3)*
AG 1 (1-1)*, ** 1 (1-1)*, ** 1 (1-1)*, **
L-NAME 1(1-2)*, ** 1 (1-1)*, ** 1 (1-1)*, **
  1. Intestinal mucositis was carried out by three subcutaneous MTX injections (2.5 mg/kg) in Wistar rats. Rats were treated intraperitoneally with the NOS inhibitors aminoguanidine (AG; 10 mg/Kg) or L-NAME (20 mg/Kg), one hour before MTX injection and daily until sacrifice, on the fifth day. Data represents the median values (and range) of microscopic scores in at least 10 animals per group. *p < 0.05 compared to normal animals (control group); **p < 0.05 compared to animals submitted to MTX-induced intestinal mucositis that received saline, observed on the 5th day. Data were analysed by using Kruskal-Wallis and Dunn's test.