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Table 1 Histopathological grading scores

From: Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents

Scores

Microscopic findings

0

Normal histological findings

1

Mucosa: villus blunting, loss of crypt architecture,

sparse inflammatory cell infiltration, vacuolization

and edema.

Normal muscular layer

2

Mucosa: villus blunting with fattened and vacuolated cells, crypt necrosis, intense inflammatory cell infiltration, vacuolization and edema

Normal muscular layer

3

Mucosa: villus blunting with fattened and vacuolated cells, crypt necrosis, intense inflammatory cell infiltration, vacuolization and edema

Muscular: edema, vacuolization, sparse neutrophil infiltration