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Table 1 Patients classified as a probable or possible based on paracetamol score (RUCAM algorithm).

From: Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series

         Use of paracetamol    
Case Sex/Age Alcohol use (g/d) ALT/AP Bili Pattern of ALI Hypersensitivity Outcome Indication Daily dose (mg) Pattern of use RUCAM Score Concomitant drugs RUCAM Score
Probable (6 to 8)
1 F/58 43 15.85/1.74 1.36 HC No Tx Osteoarthritis 650 Once a week for years till day before ALI. 8   
             Dexchlorpheniramine 7
2 F/82 0 15.32/1.95 10.41 HC Thrombocytopenia Recovered Cold 650 Daily for 10 days before ALI. 7   
             Metamizol 6
             Dextromethorphan 6
             Chlorphenamine 6
             Indapamide 6
             Indomethacin 6
             Tocopherol 5
3 F/85 0.5 22.21/1.27 12.32 HC Arthralgia, thrombocytopenia Not recovered Osteoarthritis 1950 Daily for 22 days before ALI. 7   
             Corticosteroids 6
4 F/25 24 383.33/2.35 3.64 HC Eosinophilia Recovered Cephalea 3250 Daily for 2 days before ALI. 7   
             Metoclopramide 6
             Bisacodyl 6
Possible (3 to 5)
5 M/18 13 5.27/1.24 5.88 M Fever Recovered Cephalea 650 1 day, 11 days before ALI. 5   
             Budesonide 3
6 F/23 13 50.23/2.16 9.23 HC Fever, rash Recovered Cephalea 500 1 day, 2 months before ALI. 4   
         Fever 1950 1 day, 3 months before ALI.    
         Fever 1950 3 days, between day 21 and day 13 before ALI.    
             Carbocysteine 3
             Ambroxol 3
             Benzocaine 3
             Chlorhexidine 3
7 F/35 20 61.10/0.64 22.43 HC No Recovered Dysmenorrhea 650 Once a month for last year till 11 days before ALI. 3 No -
  1. Alcohol use is expressed as a mean in grams per day in the last year; ALT, alanine aminotransferase and AP, alkaline phosphastase and Bili, bilirubin, expressed in times the upper limit of normal values; outcome at 6 months of follow-up; ALI, acute liver injury; HC, hepatocellular; M, mixed; Tx, liver transplantation.