Figure 4

Examples of acute and chronic injury. Figure 4A: Example of acute inflammatory changes. In the center if the field, polymorphonuclear leukocytes can be seen in the lamina propria and within the lumen of an injured gland. (original magnification 400×, H&E stain) Figure 4B: Example of epithelial injury. Typical example of epithelial erosion in where the superficial epithelial layer has been denuded. The deeper glandular mucosa persists and there is no granulation tissue reaction. (original magnification 200×, H&E stain) Figure 4C: Example of chronic inflammation. There is an increased population of predominantly mononuclear inflammatory cells, filling the lamina propria of the mucosa (original magnification 40×, inset 400×, H&E stain) Figure 4D: Example of fibrosis. Pig #339 showed focal fibrosis that widened the fibromuscular bile duct wall. The main image shows the expansion of the wall by collagen (blue staining). The inset shows thickening and homogenization of the collagen fiber pattern. (original magnification 100×, inset 400×, H&E stain)