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Table 3 Distribution of CYP2E1, MPO, MTHFR and ALDH2 genotypes in the BCH, ESCD, ESCC and controls, n(%)

From: Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County

Feature BCH ESCD ESCC Controls x 2 &P a
CYP2E1 G1259C      
C2/C2 4(1.5) 0 0 11(4.5) 1.519
C1/C2 83(30.8) 73(27.9) 67(29.6) 62(25.0) 0.678b
C1/C1 183(67.7) 189(72.1) 159(70.4) 173(70.5)  
MPO G463A      
G/G 221(81.8) 234(89.2) 175(77.4) 191(77.8) 15.942
A/G 49(18.2) 28(10.8) 44(19.4) 52(21.2) 0.001 b
A/A 0 0 7(3.2) 2(1.0)  
hOGG1 C326G      
G/G 43(15.9) 26(10.1) 13(5.9) 26(10.4) 24.003
C/G 123(45.7) 160(60.9) 126(55.9) 123(50.0) <0.001
C/C 104(38.4) 76(29) 86(38.2) 97(39.6)  
MTHFR C677T      
T/T 45(16.7) 85(32.4) 64(28.4) 58 (23.6) 20.705
C/T 113(41.9) 82(31.3) 85(37.5) 97 (39.4) 0.002
C/C 112(41.4) 95(36.3) 77(34.1) 91 (37.0)  
ALDH2      
G/G(2*2) 106(39.4) 145(55.3) 76(33.6) 41(16.7) 80.423
A/G(1*2) 134(49.5) 85(32.5) 129(57.1) 164(66.6) <0.001
A/A(1*1) 30(11.1) 32(12.2) 21(9.3) 41(16.7)  
  1. a P : Chi-square test was for proportions among the four groups. b : Kruskal-Wallis H test. Abbreviations: BCH, Basal cell hyperplasia; ESCD, esophageal squamous cell dysplasia; ESCC, Esophageal Squamous cell cancer.