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Table 3 Distribution of CYP2E1, MPO, MTHFR and ALDH2 genotypes in the BCH, ESCD, ESCC and controls, n(%)

From: Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County

Feature

BCH

ESCD

ESCC

Controls

x 2 &P a

CYP2E1 G1259C

     

C2/C2

4(1.5)

0

0

11(4.5)

1.519

C1/C2

83(30.8)

73(27.9)

67(29.6)

62(25.0)

0.678b

C1/C1

183(67.7)

189(72.1)

159(70.4)

173(70.5)

 

MPO G463A

     

G/G

221(81.8)

234(89.2)

175(77.4)

191(77.8)

15.942

A/G

49(18.2)

28(10.8)

44(19.4)

52(21.2)

0.001 b

A/A

0

0

7(3.2)

2(1.0)

 

hOGG1 C326G

     

G/G

43(15.9)

26(10.1)

13(5.9)

26(10.4)

24.003

C/G

123(45.7)

160(60.9)

126(55.9)

123(50.0)

<0.001

C/C

104(38.4)

76(29)

86(38.2)

97(39.6)

 

MTHFR C677T

     

T/T

45(16.7)

85(32.4)

64(28.4)

58 (23.6)

20.705

C/T

113(41.9)

82(31.3)

85(37.5)

97 (39.4)

0.002

C/C

112(41.4)

95(36.3)

77(34.1)

91 (37.0)

 

ALDH2

     

G/G(2*2)

106(39.4)

145(55.3)

76(33.6)

41(16.7)

80.423

A/G(1*2)

134(49.5)

85(32.5)

129(57.1)

164(66.6)

<0.001

A/A(1*1)

30(11.1)

32(12.2)

21(9.3)

41(16.7)

 
  1. a P : Chi-square test was for proportions among the four groups. b : Kruskal-Wallis H test. Abbreviations: BCH, Basal cell hyperplasia; ESCD, esophageal squamous cell dysplasia; ESCC, Esophageal Squamous cell cancer.