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Table 1 Tumorigenicity experiments of PLC/PRF/5 sphere-forming cells and parental cells in NOD/SCID mice

From: Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines

Cell type Cell numbers injected Tumor incidence Latency(days)
Sphere-forming cells of the 3rd generation 2 × 102 0/3 -
  5 × 102 1/3 35
  1 × 103 3/3 23
  2.5 × 103 3/3 23
  5 × 103 3/3 20
  1 × 104 3/3 16
  5 × 104 2/2 9
  1 × 105 2/2 7
  2 × 105 2/2 7
Sphere-forming cells of the 6th generation 2 × 102 0/3 -
  5 × 102 2/3 49
  1 × 103 3/3 28
Sphere-forming cells of the 9th generation 2 × 102 0/3 -
  5 × 102 1/3 40
  1 × 103 3/3 30
PLC/PRF/5 parental cells 5 × 104 0/3 -
  1 × 105 0/3 -
  2 × 105 2/3 30
  5 × 105 3/3 16
  1 × 106 2/2 9
  1. The number of tumors detected/number of injections.
  2. Approximate number of days from tumor cell injection to appearance of a tumor.