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Table 8 Evidence table of studies that examined changes in circulating ghrelin levels following H pylori eradication

From: Helicobacter pylori infection and circulating ghrelin levels - A systematic review

Reference & Country Study Team Design Healthy Gender Age category HP assess Ghrelin assay Kit Sample storage Sample type Weight Sample size Circulating Ghrelin levels after cure Follow-up (wks)
Nwokolo et al, 2003; UK [2] A Cohort Healthy Both Adults Serology and UBT Commercial RIA -20 Plasma Various 10 Increased 6
Jang et al, 2008; Korea [16] B Cohort Sick Both Adults RUT plus histology & confirmed by UBT Commercial RIA -70 Plasma Normal 16 Increased Not stated
Osawa et al, 2006; Japan [46] C Cohort Healthy Men Adults Bacterial culture & histology In-house RIA Not stated Plasma Normal 134 Decreased 12
Czesnikiewicz-Guzik et al, 2007; Poland [13] D Cohort Sick Women Adults UBT; culture of saliva & supragingival dental plaques + serology Commercial RIA -80 Plasma Not stated 49 Increased 4
Lee et al, 2010; Korea [23] B RCT Healthy Both Adults RUT, histology (Giemsa stain) ELISA -70 Plasma Normal 9 No difference 5
Choe et al, 2007, Korea [6] E Cohort Sick Both Adults histology & PCR Commercial ELISA -70 Plasma Normal 8 No difference 4
Pacifico et al, 2008; Italy [26] F Cohort Both Both Children Culture of gastric specimen or histology + RUT RIA -70 Serum Normal 22 Decreased 52
Nweneka, et al, unpublished; Gambia G Cohort Sick Both Children UBT Commercial RIA -70 Serum Low 3 Decreased 4
Isomoto et al, 2005; Japan [36] C Cohort Sick Both Adults RUT, histology (Giemsa stain) In-house RIA -80 Plasma Normal 43 No difference 4
Isomoto et al, 2005; Japan[35] C Cohort Sick Both Adults RUT, histology (Giemsa stain) In-house RIA -80 Plasma Normal 10 No difference 4
Kawashima et al, 2009; Japan [38] H Cohort Both Both Adults Serology Commercial EIA -80 Plasma Normal 49 Increased 23
Cindoruk et al, 2007; Turkey [11] I Cohort Sick Both Adults Either histology or UBT RIA -80 Plasma Normal 23 No difference 12
Isomoto et al, 2004; Japan [34] C Cohort Sick Both Adults Serology Commercial RIA -80 Plasma Normal 9 No difference 4