Helicobacter pylori infection and circulating ghrelin levels - A systematic review

Nweneka, Chidi V; Prentice, Andrew M

doi:10.1186/1471-230X-11-7

BMC Gastroenterology

Table 5 Evidence table of studies that compared circulating ghrelin levels in Hp+ and Hp- individuals

From: Helicobacter pylori infection and circulating ghrelin levels - A systematic review

Reference & Country	Study Team	Design	Healthy	Gender	Age	Method of H pylori assessment	Ghrelin assay kit	Overnight fast	Sample storage	Sample type	Weight	Sample size	Ghrelin levels in Hp+ vs Hp-
Kawashima et al, 2009; Japan [38]	A	Cohort	Both	Both	Adults	Serology	Commercial EIA	Yes	-80	Plasma	Normal	220	Lower
Plonka et al, 2006; Poland [32]	B	Cohort	Healthy	Both	Both	Modified UBT plus ELISA	Commercial RIA	Yes	-80	Serum		538	Lower
Isomoto et al, 2005; Japan[36]	C	Cohort	Sick	Both	Adults	RUT, histology (Giemsa stain)	In-house RIA	Yes	-80	Plasma	Normal	81	Lower
Roper et al, 2008; USA [18]	D	Cross-sectional	Healthy	Men	Adults	serology, histology & RUT or positive culture	Commercial EIA	Yes	-20	Serum	Normal	256	No Difference
Pacifico et al, 2008; Italy [26]	E	Cohort	Both	Both	Children	Culture of gastric specimen or histology + RUT	Commercial RIA	Yes	-70	Serum	Normal	85	No Difference
Gokcel, 2003; Turkey [3]	F	Case control	Sick	Women	Adults	Not stated	Commercial EIA	Yes	Not stated	Plasma	Normal	39	No Difference
Plonka et al, 2006; Poland [43]	B	Case control	Healthy	Both	Children	Serology and UBT	Commercial RIA	Yes	-80	Serum	Various	287	Lower
Shiotani et al, 2005; Japan [21]	G	Case control	Healthy	Both	Adults	Detection of HP IgG ab in the urine	Commercial ELISA	Yes	Not stated	Serum	Various	132	Lower
Osawa et al, 2005; Japan [40]	C	Case control	Sick	Men	Adults	Culture & histology	In-house RIA	Yes	-30	Plasma	Normal	160	Lower
Chuang et al*, 2009; Taiwan [30]	H	Cross-sectional	Sick	Men	Adults	Not described	Commercial RIA	Yes	-72	Plasma	low to normal	145	Lower
Chuang et al*, 2009; Taiwan [30]	H	Cross-sectional	Sick	Women	Adults	Not described	Commercial RIA	Yes	-72	Plasma	low to normal	196	No Difference
Alonso et al, 2007; Spain[42]	P	Cross-sectional	Sick	Both	Adults	UBT, histology (Giemsa stain)	Commercial RIA	Yes	-80	Plasma	Normal	15	Lower
Salles et al, 2006; France[19]	I	Cross-sectional	Sick	Both	Adults	UBT, serology, culture, histology & PCR	Commercial RIA	Yes	-80	Plasma	low to normal	62	Lower
Jun et al, 2007; Korea [37]	J	Cross-sectional	Sick	Both	Adults	RUT, histology (Giemsa stain)	Commercial RIA	Yes	-70	Plasma	Normal	63	No Difference
D'Onghia et al, 2007; Italy [31]	K	Case control	Both	Both	Adults	ELISA	RIA	Yes	-20	Serum	Various	79	Lower
Gao et al, 2009; China [15]	L	Case control	Healthy	Both	Adults	Serology & UBT.	Commercial RIA	Yes	-80	Plasma	Normal	100	Lower
Isomoto et al, 2005; Japan[35]	C	Cross-sectional	Sick	Both	Adults	Anti-IgG antibody, 13C-UBT, or RUT	In-house RIA	Yes	-80	Plasma	Normal	89	Lower
Isomoto et al, 2005; Japan[41]	C	Cross- sectional	Sick	Both	Adults	Serology, UBT or RUT	In-house RIA	Yes	-80	Plasma	Normal	249	Lower
An et al, 2007; Korea[33]	Q	Cohort	Sick	Both	Adults	Not stated	Commercial ELISA	Yes	-70	Plasma	Normal	41	No difference
Nishi et al, 2005; Japan [39]	C	Cross-sectional	Both	Both	Adults	Serology & UBT	In-house RIA	Yes	-80	Plasma	Normal	74	Lower
Czesnikiewicz-Guzik et al, 2005; Poland [12]	B	Cross-sectional	Healthy	Women	Adults	UBT	Not stated	Not stated	Not stated	Serum	Not Stated	100	Lower
Konturek et al, 2006; Poland [17]	B	Cross-sectional	Healthy	Both	Both	UBT & serology	Human RIA	Yes	-80	Serum	Not Stated	180	Lower
Cindoruk et al, 2007; Turkey [11]	M	Cohort	Sick	Both	Adults	Either histology or UBT	RIA	Yes	-80	Plasma	Normal	50	No Difference
Isomoto et al, 2004; Japan [34]	C	Cohort	Sick	Both	Adults	Serology	Commercial RIA	Yes	-80	Plasma	Normal	68	Lower
de Martel, 2007; USA [14]	N	Case control	Sick	Both	Adults	In-house ELISA	Commercial ELISA	Yes	-80	Serum	Various	110	No Difference
Shak et al, 2008, USA[45]	R	Cohort	Healthy	Both	Adults	Serology	Commercial EIA	Yes	-20	Plasma	Obese	24	No difference
Uzzan et al, 2007[44]	S	Cohort	Healthy	Both	Adults	Histology	Commercial RIA	Yes	Not stated	Serum	Obese	13	No difference

* These are from the same paper reporting the same study but were separated because the analysis was stratified by gender and the results for males and females were completely different; hence the decision to separate them.

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ISSN: 1471-230X

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