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Table 5 Evidence table of studies that compared circulating ghrelin levels in Hp+ and Hp- individuals

From: Helicobacter pylori infection and circulating ghrelin levels - A systematic review

Reference & Country Study Team Design Healthy Gender Age Method of H pylori assessment Ghrelin assay kit Overnight fast Sample storage Sample type Weight Sample size Ghrelin levels in Hp+ vs Hp-
Kawashima et al, 2009; Japan [38] A Cohort Both Both Adults Serology Commercial EIA Yes -80 Plasma Normal 220 Lower
Plonka et al, 2006; Poland [32] B Cohort Healthy Both Both Modified UBT plus ELISA Commercial RIA Yes -80 Serum   538 Lower
Isomoto et al, 2005; Japan[36] C Cohort Sick Both Adults RUT, histology (Giemsa stain) In-house RIA Yes -80 Plasma Normal 81 Lower
Roper et al, 2008; USA [18] D Cross-sectional Healthy Men Adults serology, histology & RUT or positive culture Commercial EIA Yes -20 Serum Normal 256 No Difference
Pacifico et al, 2008; Italy [26] E Cohort Both Both Children Culture of gastric specimen or histology + RUT Commercial RIA Yes -70 Serum Normal 85 No Difference
Gokcel, 2003; Turkey [3] F Case control Sick Women Adults Not stated Commercial EIA Yes Not stated Plasma Normal 39 No Difference
Plonka et al, 2006; Poland [43] B Case control Healthy Both Children Serology and UBT Commercial RIA Yes -80 Serum Various 287 Lower
Shiotani et al, 2005; Japan [21] G Case control Healthy Both Adults Detection of HP IgG ab in the urine Commercial ELISA Yes Not stated Serum Various 132 Lower
Osawa et al, 2005; Japan [40] C Case control Sick Men Adults Culture & histology In-house RIA Yes -30 Plasma Normal 160 Lower
Chuang et al*, 2009; Taiwan [30] H Cross-sectional Sick Men Adults Not described Commercial RIA Yes -72 Plasma low to normal 145 Lower
Chuang et al*, 2009; Taiwan [30] H Cross-sectional Sick Women Adults Not described Commercial RIA Yes -72 Plasma low to normal 196 No Difference
Alonso et al, 2007; Spain[42] P Cross-sectional Sick Both Adults UBT, histology (Giemsa stain) Commercial RIA Yes -80 Plasma Normal 15 Lower
Salles et al, 2006; France[19] I Cross-sectional Sick Both Adults UBT, serology, culture, histology & PCR Commercial RIA Yes -80 Plasma low to normal 62 Lower
Jun et al, 2007; Korea [37] J Cross-sectional Sick Both Adults RUT, histology (Giemsa stain) Commercial RIA Yes -70 Plasma Normal 63 No Difference
D'Onghia et al, 2007; Italy [31] K Case control Both Both Adults ELISA RIA Yes -20 Serum Various 79 Lower
Gao et al, 2009; China [15] L Case control Healthy Both Adults Serology & UBT. Commercial RIA Yes -80 Plasma Normal 100 Lower
Isomoto et al, 2005; Japan[35] C Cross-sectional Sick Both Adults Anti-IgG antibody, 13C-UBT, or RUT In-house RIA Yes -80 Plasma Normal 89 Lower
Isomoto et al, 2005; Japan[41] C Cross- sectional Sick Both Adults Serology, UBT or RUT In-house RIA Yes -80 Plasma Normal 249 Lower
An et al, 2007; Korea[33] Q Cohort Sick Both Adults Not stated Commercial ELISA Yes -70 Plasma Normal 41 No difference
Nishi et al, 2005; Japan [39] C Cross-sectional Both Both Adults Serology & UBT In-house RIA Yes -80 Plasma Normal 74 Lower
Czesnikiewicz-Guzik et al, 2005; Poland [12] B Cross-sectional Healthy Women Adults UBT Not stated Not stated Not stated Serum Not Stated 100 Lower
Konturek et al, 2006; Poland [17] B Cross-sectional Healthy Both Both UBT & serology Human RIA Yes -80 Serum Not Stated 180 Lower
Cindoruk et al, 2007; Turkey [11] M Cohort Sick Both Adults Either histology or UBT RIA Yes -80 Plasma Normal 50 No Difference
Isomoto et al, 2004; Japan [34] C Cohort Sick Both Adults Serology Commercial RIA Yes -80 Plasma Normal 68 Lower
de Martel, 2007; USA [14] N Case control Sick Both Adults In-house ELISA Commercial ELISA Yes -80 Serum Various 110 No Difference
Shak et al, 2008, USA[45] R Cohort Healthy Both Adults Serology Commercial EIA Yes -20 Plasma Obese 24 No difference
Uzzan et al, 2007[44] S Cohort Healthy Both Adults Histology Commercial RIA Yes Not stated Serum Obese 13 No difference
  1. * These are from the same paper reporting the same study but were separated because the analysis was stratified by gender and the results for males and females were completely different; hence the decision to separate them.