Figure 4

Evaluation of treatment efficacy in chronic DSS-induced colitis. Values are expressed as mean (dot or bar) ± SD (whisker). (A) Weight change during therapy. Body weight change was calculated for each mouse by dividing its body weight on the specified day by body weight at day 0 (body weight at the beginning of therapy) and expressed as percentage. (B) DAI (C) Colon Length (cm) (D) Serum haptoglobin concentration (mg/ml) and (E) Histological grade. The differences among experimental groups are analyzed with either two-way analysis of variance (ANOVA) with Bonferroni post-hoc test (Weight change; *P < 0.05; **P < 0.01; ***P < 0.001 vs. PBS-treated) or one-way ANOVA with Tukey's multiple comparison test (*P < 0.05; **P < 0.01; ***P < 0.001). Data are pooled from two independent experiments, each with 5 mice per group.