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Table 5 Diagnostic accuracy of the ALP, bilirubin, albumin, platelet count and fibrosis-cirrhosis index (FCI) for the prediction of F0-F1 stage and hepatic cirrhosis in chronic HCV infected patients (n = 157)

From: A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

Marker Cutoff Interpretation AUC [95% CI] Spe% Sen% PPV% NPV%
ALP
< 120 F0-F1 (n = 68) F2-F4 (n = 89) 0.829 [0.760-0.897] 69.6 85.2 68.2 86.1
  58/10 27/62      
> 240 F4 (n = 21) F0-F3 (n = 136) 0.931 [0.882-0.981] 91.9 80.9 60.7 96.9
  17/4 11/125      
Bilirubin
< 0.95 F0-F1 (n = 68) F2-F4 (n = 89) 0.729 [0.643-0.815] 68.1 85.2 67.4 85.7
  58/10 28/60      
> 1.5 F4 (n = 21) F0-F3 (n = 136) 0.889 [0.816-0.962] 95.5 66.6 70 94.8
  14/7 6/130      
Albumin
> 4.1 F0-F1 (n = 68) F2-F4 (n = 89) 0.812 [0.738-0.886] 67.4 100 70.1 100
  68/0 29/60      
< 3.85 F4 (n = 21) F0-F3 (n = 136) 0.879 [0.796-0.962] 92.6 71.4 60 95.4
  15/6 10/126      
Platelet count
> 150 F0-F1 (n = 68) F2-F4 (n = 89) 0.935[0.900-0.970] 69.6 98.5 71.2 98.4
  67/1 27/62      
< 100 F4 (n = 21) F0-F3 (n = 136) 0.990[0.977-1.002] 98.5 80.9 89.4 97.1
  17/4 2/134      
FCI
< 0.130 F0-F1 (n = 68) F2-F4 (n = 89) 0.932[0.895-0.969] 86.5 80.8 82.1 85.5
  55/13 12/77      
> 1.25 F4 (n = 21) F0-F3 (n = 136) 0.996[0.989-1.002] 100 85.7 100 97.8
  18/3 0/136      
  1. Spearman rank correlation coefficient (R-index) for ALP = 0.716, bilirubin = 0.597, albumin = -0.700, platelet count = -0.817 and FCI = 0.818.