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Table 3 Validity of serum AAR, APRI, FIB-4 and FI in 157 HCV infected patients

From: A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

AAR
Cutoff value Spe% Sen% PPV% NPV% F0-F3 (n = 136 ) F4 (n = 21) AUC [95% CI]
< 1 42.8 67.6 88.4 16.9 92/44 12/9 0.468[0.377-0.559]
> 1 67.6 42.8 16.9 88.4 44/92 9/12 0.610[0.483-0.738]
APRI
Cutoff value Spe% Sen% PPV% NPV% F0-F1 (n = 68) F2-F4 (n = 89) AUC [95% CI]
< 0.5 97.7 19.1 86.6 61.2 13/55 2/87 0.715[0.635-0.795]
> 1.5 67.6 34.8 58.4 44.2 22/46 31/58 0.876[0.782-0.971]
FIB-4
Cutoff value Spe% Sen% PPV% NPV% F0-F2 (n = 102) F3-F4 (n = 55 ) AUC [95% CI]
< 1.45 85.4 51 86.6 48.4 52/50 8/47 0.732 [0.655-0.809]
> 3.25 82.3 59.2 64 79.2 18/84 33/22 0.545[0.456-0.635]
FI
Cutoff value Spe% Sen% PPV% NPV% F0-F1 (n = 68) F2-F4 (n = 89) AUC [95% CI]
< 2.1 58.4 100 64.7 100 68/0 37/52 0.939[0.903-0.974]
Cutoff value Spe% Sen% PPV% NPV% F0-F3 (n = 136) F4 (n = 21) AUC [95% CI]
> 3.3 100 38.1 100 91.2 0/136 8/13 0.990[0.979-1.001]
  1. Spearman rank correlation coefficient (R-index) for AAR = 0.130, APRI = 0.444, FIB-4 = 0.494 and FI = 0.578