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Table 2 Demographics and clinical characteristics of patients enrolled following acute overdose, repeated overdose or after ingestion of a non-acetaminophen hepatotoxin.

From: Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

Patient number Age/
Sex
Peak ALT IU/L Case description
    Acute acetaminophen treated within 8 hours of ingestion
D-01 26 F 37 40 unknown strength tabs. 4.5 hr [APAP] 230 mcg/ml. 6.5 hrs to NAC.
D-02 20 F 18 20 g. 2.5 hr [APAP] 262 mcg/ml. 5 hr to NAC.
D-04 35 F 26 10-13 g. 6 hr [APAP] 177 mcg/ml. 7 hr to NAC.
D-06 20 F 17 Approx 30 tabs unknown strength. 4 hr [APAP] 319 mcg/ml. 6 hr to NAC.
SH-03 55 F 16 10.4 g. 4 hr [APAP] 184 mcg/ml. 6 hr to NAC.
SH-04 22 M 9903 25 g. 5 hr [APAP] 221 mcg/ml. 7 hr to NAC.
SH-05 38 F 57 39 g. 13 hr [APAP] 296 mcg/ml. 3.5 hr to NAC.
SH-06 16 F 14 "3 handfuls" of unknown product. 4 hr [APAP] 293 mcg/ml. 5.5 Hr to NAC.
SH-07 24 M 27 13-16.5 g. 6 hr [APAP] 235 mcg/ml. 8 hr to NAC.
SH-12 42 M 30 Unknown amount. 4 hr [APAP] 215 mcg/ml. 7 hr to NAC.
UCH-05 27 F 1729 48 gm. 1 hr [APAP] 557 mcg/ml. 5.5 hr to NAC.
UCH-06 51 F 22 19.5-53 g. 3 hr [APAP] 467 mcg/ml. 5 hr to NAC.
    Acute acetaminophen treated more than 8 hours post ingestion
D-05 25 F 18 Unknown amount. 8 hr [APAP] 373 mcg/ml. 9 hr to NAC.
D-07 38 M 8880 7 g. 41 hr [APAP] 9 mcg/ml. 49 hr to NAC. Hep C.
D-08 37 F 1999 5 g × 2 8 hrs apart. 12 hr (from first ingestion) [APAP] 121 mcg/ml. 13 hr to NAC.
SH-08 37 F 1362 13-16 g. 10 hr [APAP] 89 mcg/ml. Time to NAC 15 hr.
UCH-01 52 F 457 15-25 g. 24 hr [APAP] 10 mcg/ml. Time to NAC 26 hr.
UCH-07 40 F 2083 Unknown amt. 27 hr [APAP] 336 mcg/ml. Time to NAC 28 hr.
UCH-14 41 F 4372 30 g. 36 hr [APAP] 5.6 mcg/ml. Time to NAC 36 hr.
    Repeated acetaminophen ingestion
D-00 27 M 741 Approximately 10 g/day for 4 d for dental pain. Presenting [APAP] 0 mcg/ml.
D-18 17 M 229 Approximately 4 g/day for 2 d then 8 g/day for 1 day for prevertebral abscess. Presenting [APAP] 20 mcg/ml.
D-19 44 F 2862 4-6 g/day for 4 days then 25-50 g OD. 60 hr [APAP] 0 mcg/ml. NAC 14.5 hr post OD.
UCH-03 28 F 3189 2-3 tabs unknown str every 2-4 hrs for 7 d. Presenting [APAP] 16 mcg/ml.
UCH-08 29 F 2099 Approx 12 gm over 14 hrs. Presenting [APAP] 0 mcg/ml.
UCH-09 38 F 284 21 g over 5 d. Presenting [APAP] 0 mcg/ml. CMV hepatitis on liver biopsy.
UCH-11 24 M 7979 5-7.5 g/day for 4 d. presenting [APAP] 0 mcg/ml.
    Acetaminophen ingestion-not able to determine time course
UCH-15 29 F 131 Unknown amt over several hours. Presenting [APAP] 36 mcg/ml. Polypharmacy OD.
    Ingestion of other hepatotoxins
D-16 12 M 2346 Isoniazd-induced liver injury during therapeutic use.
SH-01 47 M 174 1500 mg of tramadol. Alcoholic
SH-02 24 M 18 9.5 g of valproic acid.
SH-09 18 F 18 8 g phenytoin.
  1. [APAP]- serum acetaminophen concentration, NAC- acetylcysteine, ALT- alanine aminotransferase.