Table 2 Demographics and clinical characteristics of patients enrolled following acute overdose, repeated overdose or after ingestion of a non-acetaminophen hepatotoxin.

D-01

26 F

37

40 unknown strength tabs. 4.5 hr [APAP] 230 mcg/ml. 6.5 hrs to NAC.

D-02

20 F

18

20 g. 2.5 hr [APAP] 262 mcg/ml. 5 hr to NAC.

D-04

35 F

26

10-13 g. 6 hr [APAP] 177 mcg/ml. 7 hr to NAC.

D-06

20 F

17

Approx 30 tabs unknown strength. 4 hr [APAP] 319 mcg/ml. 6 hr to NAC.

SH-03

55 F

16

10.4 g. 4 hr [APAP] 184 mcg/ml. 6 hr to NAC.

SH-04

22 M

9903

25 g. 5 hr [APAP] 221 mcg/ml. 7 hr to NAC.

SH-05

38 F

57

39 g. 13 hr [APAP] 296 mcg/ml. 3.5 hr to NAC.

SH-06

16 F

14

"3 handfuls" of unknown product. 4 hr [APAP] 293 mcg/ml. 5.5 Hr to NAC.

SH-07

24 M

27

13-16.5 g. 6 hr [APAP] 235 mcg/ml. 8 hr to NAC.

SH-12

42 M

30

Unknown amount. 4 hr [APAP] 215 mcg/ml. 7 hr to NAC.

UCH-05

27 F

1729

48 gm. 1 hr [APAP] 557 mcg/ml. 5.5 hr to NAC.

UCH-06

51 F

22

19.5-53 g. 3 hr [APAP] 467 mcg/ml. 5 hr to NAC.

Acute acetaminophen treated more than 8 hours post ingestion

D-05

25 F

18

Unknown amount. 8 hr [APAP] 373 mcg/ml. 9 hr to NAC.

D-07

38 M

8880

7 g. 41 hr [APAP] 9 mcg/ml. 49 hr to NAC. Hep C.

D-08

37 F

1999

5 g × 2 8 hrs apart. 12 hr (from first ingestion) [APAP] 121 mcg/ml. 13 hr to NAC.

SH-08

37 F

1362

13-16 g. 10 hr [APAP] 89 mcg/ml. Time to NAC 15 hr.

UCH-01

52 F

457

15-25 g. 24 hr [APAP] 10 mcg/ml. Time to NAC 26 hr.

UCH-07

40 F

2083

Unknown amt. 27 hr [APAP] 336 mcg/ml. Time to NAC 28 hr.

UCH-14

41 F

4372

30 g. 36 hr [APAP] 5.6 mcg/ml. Time to NAC 36 hr.

Repeated acetaminophen ingestion

D-00

27 M

741

Approximately 10 g/day for 4 d for dental pain. Presenting [APAP] 0 mcg/ml.

D-18

17 M

229

Approximately 4 g/day for 2 d then 8 g/day for 1 day for prevertebral abscess. Presenting [APAP] 20 mcg/ml.

D-19

44 F

2862

4-6 g/day for 4 days then 25-50 g OD. 60 hr [APAP] 0 mcg/ml. NAC 14.5 hr post OD.

UCH-03

28 F

3189

2-3 tabs unknown str every 2-4 hrs for 7 d. Presenting [APAP] 16 mcg/ml.

UCH-08

29 F

2099

Approx 12 gm over 14 hrs. Presenting [APAP] 0 mcg/ml.

UCH-09

38 F

284

21 g over 5 d. Presenting [APAP] 0 mcg/ml. CMV hepatitis on liver biopsy.

UCH-11

24 M

7979

5-7.5 g/day for 4 d. presenting [APAP] 0 mcg/ml.

Acetaminophen ingestion-not able to determine time course

UCH-15

29 F

131

Unknown amt over several hours. Presenting [APAP] 36 mcg/ml. Polypharmacy OD.

Ingestion of other hepatotoxins

D-16

12 M

2346

Isoniazd-induced liver injury during therapeutic use.

SH-01

47 M

174

1500 mg of tramadol. Alcoholic

SH-02

24 M

18

9.5 g of valproic acid.

SH-09

18 F

18

8 g phenytoin.