Table 5 Proportion of patients showing satisfactory improvement of individual symptoms

Stomach pain

71.7 (1107/1544)

64.1 (257/401)

7.6

(2.4, 12.8)

0.003

83.7 (1018/1216)

74.9 (230/307)

8.8

(3.5, 14.1)

< 0.001

Heavy feeling in the stomach

61.7 (1467/2379)

45.9 (299/652)

15.8

(11.5, 20.1)

< 0.001

77.0 (1465/1903)

64.0 (330/516)

13.0

(8.5, 17.6)

< 0.001

Nausea

72.1 (1079/1497)

62.0 (246/397)

10.1

(4.8, 15.4)

< 0.001

85.1 (1013/1191)

74.2 (227/306)

10.9

(5.6, 16.2)

< 0.001

Irritating sensation in the throat

68.4 (726/1061)

69.1 (170/246)

-0.7

(-7.1, 5.7)

0.836

77.8 (657/844)

71.4 (135/189)

6.4

(-0.6, 13.4)

0.059

Acid or bitter taste due to refluxed fluid

70.7 (1502/2124)

58.4 (320/548)

12.3

(7.8, 16.9)

< 0.001

85.4 (1492/1747)

72.9 (315/432)

12.5

(8.0, 17.0)

< 0.001

Stomach bloating sensation

66.4 (878/1322)

56.7 (202/356)

9.7

(3.9, 15.4)

< 0.001

81.5 (882/1082)

74.0 (211/285)

7.5

(1.9, 13.1)

0.005

Choking sensation in the throat

66.8 (641/959)

64.7 (152/235)

2.2

(-4.6, 9.0)

0.530

78.6 (611/777)

68.9 (126/183)

9.8

(2.5, 17.1)

0.005

Burning sensation from stomach or lower chest toward the neck

78.9 (1097/1391)

69.2 (225/325)

9.6

(4.2, 15.1)

< 0.001

88.4 (989/1119)

77.0 (207/269)

11.4

(6.1, 16.8)

< 0.001

Belching

60.7 (940/1548)

49.3 (197/400)

11.5

(6.0, 16.9)

< 0.001

74.3 (947/1275)

64.4 (206/320)

9.9

(4.1, 15.7)

< 0.001

Loss of appetite

75.4 (771/1022)

66.2 (178/269)

9.3

(3.0, 15.5)

0.002

85.3 (721/845)

75.1 (154/205)

10.2

(3.8, 16.6)

< 0.001

Early satiety

68.8 (698/1015)

62.0 (178/287)

6.7

(0.5, 13.0)

0.031

80.5 (656/815)

72.0 (167/232)

8.5

(2.1, 14.9)

0.005

Coughing

62.9 (450/715)

58.9 (103/175)

4.1

(-4.0, 12.2)

0.319

74.6 (432/579)

68.7 (101/147)

5.9

(-2.4, 14.2)

0.148