Figure 2
From: In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Effect of propofol on heart rates and indices of cardiac contractility ex vivo (Langendorff preparations) at day 7 in a rat model of obstructive jaundice and sham-operated controls. (A) Heart rates. (B) Maximal rate of left ventricular pressure rise (+dT/dt). (C) Left ventricular end-systolic pressure (LVESP); (D) Left ventricular end-diastolic pressure (LVEDP). (E) Maximal rate of left ventricular pressure declining (-dP/dtmax ). Results are expressed as means ± SEM (n = 10); SO, sham-operated control; BDL, bile duct ligation; HR, heart rate; Abscissa, propofol concentrations; ordinate, percent change in a given variable compared with baseline; closed circle, sham-operated control; open circle, BDL group. For each twitch parameter, original hemodynamic data from the groups were compared by two-way ANOVA followed by the Bonferroni test. * P < 0.05 vs sham-operated controls (same propofol concentration).