Figure 1From: The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair Fascin is overexpressed in inflammatory bowel disease and in colonic epithelium actively undergoing restitution and regeneration. Fascin immunoreactivity was detected in specimens of human colorectal mucosa by immunoperoxidase staining. A: Diverticulitis resection margin showing positive staining in the crypt base - 200 × magnification. B: Ulcerative colitis showing positive staining in the base of the elongated crypts - 100 ×. C: Crohn's colitis showing strong positive staining toward the base of the elongated crypts - 100 ×. D: Crohn's colitis showing patchy fascin immunoreactivity throughout the gland - 200 ×. E: Ulcerative colitis with low-grade dysplasia showing strong and widespread fascin expression - 100 ×. F: Ulcerative colitis with high-grade dysplasia showing strong and widespread fascin expression - 200 ×. G: Ulcerative colitis showing fascin staining in the flattened epithelial cells undertaking restitution - 200 ×. H: enlargement of an area of panel G illustrating the fascin-positive epithelial cells (arrowheads). I: fascin positive epithelial cells undertaking restitution in a sample of Crohn's colitis. J: A regenerative polyp in a sample of ulcerative colitis showing fascin positivity in the newly forming crypts - 200 ×. K & L: Fascin expression in branching crypts (arrowheads) in regenerating ulcerative colitis tissue - 200 ×.Back to article page