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Table 2 MLH1 mutations detected in gastric cancer cases compared with controls.

From: The MLH12101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males

Genotypes

Cases

Controls

P a

OR (95% CI) b

P b

-93 G>A

  

0.736

  

GG

36 (15.3%)

42(17.5%)

 

1.00

 

GA

111 (47.0%)

114(47.5%)

   

AA

89 (37.7%)

84(35.0%)

   

GA+AA

200 (84.7%)

198(82.5%)

 

1.18 (0.72-1.92)

0.510

A allele

61.2%

58.8%

0.435

  

-28A>G

  

1.000c

  

AA

232 (98.3%)

236 (98.3%)

 

1.00

 

AG

4 (1.7%)

4 (1.7%)

 

1.02 (0.25-4.14)

0.978

G allele

0.85%

0.83%

1.000 c

  

649C>T (R217C)

  

0.120 c

  

CC

231 (97.9%)

239 (99.6%)

 

1.00

 

CT

5(2.1%)

1 (0.4%)

 

5.25 (0.61-45.45)

0.132

T allele

1.1%

0.2%

0.121 c

  

655A>G (I219V)

  

0.257

  

AA

229 (97.0%)

228 (95.0%)

 

1.00

 

AG

7 (3.0%)

12 (5.0%)

 

0.58 (0.22-1.50)

0.262

G allele

1.5%

2.5%

0.262

  

1151T>A (V384D)

  

1.000 c

  

TT

232 (98.3%)

236 (98.3%)

   

TA

4 (1.7%)

4 (1.7%)

 

1.02 (0.25-4.15)

0.976

A allele

0.85%

0.83%

1.000 c

  

2101C>A (Q701K)

  

0.120

  

CC

228 (96.6%)

237 (98.8%)

 

1.00

 

CA

8 (3.4%)

3 (1.3%)

 

2.77 (0.73 -10.57)

0.136

A allele

1.7%

0.6%

0.122

  
  1. a Two-sided χ 2 test for either genotype distribution or allele frequency.
  2. b Unconditional logistic regression adjusted by age and gender
  3. c Fisher's exact test