Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C

Table 5 Summary of correct classification rates (%) and score/grade discrepancy (2 bottom lines).

	Liver biopsy		FibroMeter								Fibrotest				Fibroscan
			2G				3G
Population #	1	1	1	2	3	4	1	2	3	4	1	2	3	4	3	4
Pathologist	Local ^a	Expert	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Metavir F_M staging	52.2/64.4	82.2	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Binary diagnosis ^b	77.1/85.9	91.4	75.3	78.1*	75.2	77.7	75.5	77.9*	74.0	76.8	74.2	74.5*	71.3	75.2	73.7	75.2
Fibrosis class classification ^c	-	-	76.3	74.9*	68.7	68.2	89.0	86.9*	77.1	83.4	34.3	37.9*	42.5	33.5	64.9	50.7
Discrepancy score ^d	0.55/0.40	0.17	0.30	0.30	0.36	0.38	0.11	0.14	0.23	0.17	0.86	0.84	0.86	0.92	0.50	0.64
Significant discrepancy (%) ^e	7.3/4.9	0.0	5.6	4.6	5.7	6.0	0.5	0.7	0.9	0.9	17.2	18.2	21.3	22.2	12.9	12.3

Results are presented according to different classifications and diagnostic means in the 4 populations with hepatitis C.
^a The first figure refers to the expert as reference and the second to the consensus reading as reference
^b for significant fibrosis; results indicated with * were provided by a previous study [8]
^c by blood test; results indicated with * were provided by a previous study [8]
^d Mean
^e ≥ 2 F_M stage

ISSN: 1471-230X