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Table 3 Reported Cases with Sites of Disease and Histologic Findings

From: Autoimmune enteropathy with a CD8+ CD7-T-cell small bowel intraepithelial lymphocytosis: case report and literature review

Reference Gender, Age Involved sites Intra-epithelial Lamina propria
16 F, 38 Small intestine 46%a NR
16 F, 47 Small intestine 42%a NR
8 F, 39 Stomach, duodenum, jejunum, colon, recto-sigmoid 12%a (normal), decreased CD3- CD103+, aberrant CD3+CD4+CD103-, increased HLA-II expression on CD3+ Lympho-plasmacytic infiltrate (CD3+)
19 F, 50 Duodenum, colon Duodenum: IEL = 48/100, CD3 + 50/mm (elevated), eosinophils (some);
Colon: normal
Colon: lympho-plasmacytic infiltrate, eosinophils (some)
18 F, 82 Duodenum Lympho-plasmacytic infiltrate NR
20 M, 67 colon NR NR
20 F, 39 Small intestine, colon NR NR
22 F, 58 Stomach, duodenum, jejunum, colon, rectosigmoid Duodenum: IEL = 10-20/100, CD8 + preponderance
Jejunum: lymphocytosis
Colon: chronic inflammation, CD4 + , CD8 + , CD19 + /20 + , CD68 +
Duodenum: CD3+ and CD43+ lymphocytosis with CD68 + (macrophages)
Jejunum: Inflammatory infiltrate
15 M, 54 Duodenum, ileum Duodenum: IEL = 28/100 (normal), 50% CD8 + , oligoclonal TCR αβ +
Ileum: lymphocytosis
Colon: lymphocytosis
NR
3 M, 19 Duodenum, ileum, colon Normal NR
17 F, 35 Duodenum IEL = > 40/100
52% CD3+
NR
21 M, 59 Stomach, colon, ileum Normal Colon + Ileum: lympho-plasmacytic infiltrate, occasional neutrophils and eosinophils
Stomach + Colon + Ileum: CD8 + and CD45RO + preponderance
4 M, 21 Duodenum IEL = 50/100
CD8+ preponderance
CD4+ preponderance, occasional CD8+ and neutrophils, rare CD20+
24 M, 58 Duodenum, ileum, colon Lymphocytosis Lympho-plasmacytic infiltrate
  1. Abbreviations:
  2. IEL: Intra-epithelial lymphocytosis
  3. a: expressed as a percentage of total cells