Figure 1

Effect of treatment with RLS or Saline on ALT/AST in APAP-induced ALI model. Figure 1A and 1B: ALI was induced in C57Bl/6 male mice with a single dose of APAP (300 mg/kg) by i.p. injection. 2 hrs following APAP injection, the animals were treated with 1 mL RLS or 1 mL saline every 12 hrs. ALT and AST were measured 24 hrs after APAP injection (n = 6 survival mice for each group). Results are means ± SEM. * indicates P < 0.05 versus control. Figure 1C and 1D: three separate groups of mice were used. ALI was induced the same as Figure 1A. 2 hrs after APAP challenge, the animals were given the same treatment every 12 hrs for a total of 48 hrs. ALT and AST were measured 48 hrs after APAP injection (n = 5 mice for each group). Figure 1E and 1F: three separate groups of mice were used. ALI was induced the same as Figure 1A and the same treatment was given every 12 hrs for a total of 72 hrs. ALT and AST were measured 72 hrs after APAP injection (n = 6 survival mice for each group). Results are means ± SEM. * indicates p < 0.05 vs. control; † indicates p < 0.05 vs. saline.