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Figure 3 | BMC Gastroenterology

Figure 3

From: Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma

Figure 3

PXR mRNA levels and nuclear translocation of PXR protein in esophageal cell lines stimulated with bile acids. (A) PXR mRNA levels are significantly higher in OE19 than in HET1A (P = 0.02). Bile stimulation with 50 μM or 100 μM of TLCA did not affect PXR mRNA levels compared to unstimulated conditions. (B) After immunofluorescent staining of PXR (red) and nuclei (green), localization in OE19 cells was visualized by a confocal laser microscope (1000×). In unstimulated cells, PXR was predominantly found in the cytoplasm. Upon 24 h of stimulation with 50 μM of TLCA, PXR translocation from the cytoplasm to the nuclei was observed.

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