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Table 5 Meta-analysis of studies comparing conventional colonoscopy to NBI system.

From: Narrow-band imaging does not improve detection of colorectal polyps when compared to conventional colonoscopy: a randomized controlled trial and meta-analysis of published studies

Study (Year)

Outcome

Conventional colonoscopy (N)

NBI system (N)

RR* WMD** (95%CI)

Heterogeneity (I2) §

Adler 2009

East 2009

Inoue 2008

Kaltenbach 2008

Sabbagh 2011

Mean number of polyps

1241

1238

WMD -0.07 (-0.21 to 0.07)

68%

Adler 2009

Adler 2008

East 2009

Inoue 2008

Kaltenbach 2008

Paggi 2009

Rex 2007

Sabbagh 2011

Mean number of adenomas

1768

1749

WMD -0.08 (-0.17 to 0.01)

62%

Adler 2009

Adler 2008

Inoue 2008

Kaltenbach 2008

Sabbagh 2011

Rate of patients with al least one polyp

1336

1330

RR 0.90 (0.73 to1.11)

70%

Adler 2009

Adler 2008

East 2009

Inoue 2008

Kaltenbach 2008

Paggi 2009

Rex 2007

Sabbagh 2011

Rate of patients with at least one adenoma

1763

1749

RR 0.96 (0,88 to 1.04)

0%

Adler 2009

Adler 2008

Paggi 2009

Sabbagh 2011

Rate of patients with carcinoma

1181

1169

RR 1.20 (0.58 to 2.47)

0%

  1. *Relative Risk and 95% confidence intervals (CI) for dichotomous outcomes were calculated by the Mantel-Haenszel fixed-effects model when I2 < 50%. Relative Risk and 95% confidence intervals (CI) for dichotomous outcomes were calculated by the Mantel-Haenszel random-effects model when I2 > 50%.
  2. **Mean difference and 95% confidence intervals (CI) for continuous outcomes were calculated using the inverse variance and the fixed-effects model when I2 < 50%. Mean difference and 95% confidence intervals (CI) for continuous outcomes were calculated using the inverse variance and the random-effects model when I2 > 50%.
  3. § Low, moderate, and high levels of heterogeneity approximately correspond to I2 values of 25%, 50% and 75%, respectively [35].