A simple index of lipid overaccumulation is a good marker of liver steatosis

BMC Gastroenterology

Table 2 Proportional-odds logistic regression models.

	Model 1 OR [95%CI] p-value	Model 2 OR [95%CI] p-value	Model 3 OR [95%CI] p-value	Model 4 OR [95%CI] p-value	Model 5 OR [95%CI] p-value
	4.45	4.42	4.28	4.25	4.14
lnLAP	[3.42 to 5.79]	[3.36 to 5.80]	[3.28 to 5.58]	[3.24 to 5.58]	[3.17 to 5.40] p < 0.001
	p < 0.001	p < 0.001	p < 0.001	p < 0.001
Male sex	--	1.78	1.88	1.72	1.79
		[1.23 to 2.57]	[1.31 to 2.69]	[1.18 to 2.49]	[1.25 to 2.58]
		p = 0.002	p < 0.001	p = 0.004	p = 0.011
Age (years)	--	0.99	--	0.99	--
		[0.98 to 1.01]		[0.98 to 1.01]
		p = 0.232		p = 0.316
SLD	--2;	--	--	1.70	1.72
				[1.20 to 2.41]	[1.21 to 2.44]
				p = 0.003	p < 0.001
n	588	588	588	588	588
p-Brant test	0.560	0.518	0.704	0.273	0.331
p-HL none vs. intermediate + severe steatosis	0.021	0.402	0.836	0.584	0.315
p-HL none + intermediate vs. severe steatosis	0.236	0.383	0.398	0.594	0.676
AUROC	0.78	0.79	0.79	0.80	0.79
none vs. (intermediate + severe) steatosis	[0.74 to 0.82]	[0.76 to 0.83]	[0.76 to 0.83]	[0.76 to 0.83]	[0.76 to 0.83]
AUROC	0.78	0.79	0.79	0.80	0.80
(none + intermediate) vs. severe steatosis	[0.74 to 0.82]	[0.75 to 0.83]	[0.76 to 0.83]	[0.76 to 0.84]	[0.76 to 0.84]
BIC	1015	1014	1009	1012	1007

Abbreviations: OR = odds ratio; 95%CI = 95% confidence intervals; p-value = p-value for the regression coefficient (exponentiated and presented as odds ratio); lnLAP = natural logarithm of the lipid accumulation product; SLD = suspected liver disease; p-Brant = p-value associated with the Brant test of proportional odds; p-HL = p-value associated with the Hosmer Lemeshow statistics of the 2 binary models underlying the proportional-odds model; AUROC = area under the ROC curve; BIC = Bayesian information criterion.

ISSN: 1471-230X