Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection

Table 4 Multivariate analyses of the determinants of FASN concentrations in HCV co-infected patients (n = 115)

	β Coefficient	95% CI	P Values
Age, years	0.144	-0.409 to 1.327	0.292
Gender, male	0.134	-15.86 to 5.14	0.327
BMI, kg/m ²	0.086	-0.75 to 1.677	0.444
Patients treated with PI or NNRTI, n	-0.295	-23.92 to 1.56	0.041
Lipodystrophy, n	-0.202	-18.147 to 2.19	0.121
CD4+ T cell count, cells/mm ³	0.121	-0.005 to 0.19	0.260
Undetectable HIV-1 viral load ^a , n	0.053	-6.559 to 10.55	0.639
HDL-cholesterol, mmol/L	0.046	-12.89 to 17.55	0.759
Triglyceride, mmol/L	0.050	-2.45 to 3.49	0.726
Apolipoprotein A-I, g/L	0.230	-5.063 to 36.14	0.135
MCP-1, pg/mL	0.271	2.403 to 0.021	0.021
Insulin, pmol/L	-0.009	-0.040 to 0.037	0.937
IL-8, ng/L	0.025	-0.012 to 0.016	0.828
hsCRP, mg/L	-0.108	-1.00 to 0.328	0.312
Alanine aminotransferase, μKat/L	0.599	5.154 to 18.48	0.001
Aspartate aminotransferase, μKat/L	-0.073	-9.98 to 6.36	0.668

Dependent variable: FASN concentration (μg/L)
BMI: body-mass index; NNRTI: non-nucleoside analogues reverse transcriptase inhibitors; PI: protease inhibitors, hsCRP: high sensitive C-reactive protein.
^aLimit of detection was 40 copies/mL

ISSN: 1471-230X