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Table 4 Multivariate analyses of the determinants of FASN concentrations in HCV co-infected patients (n = 115)

From: Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection

  β Coefficient 95% CI P Values
Age, years 0.144 -0.409 to 1.327 0.292
Gender, male 0.134 -15.86 to 5.14 0.327
BMI, kg/m 2 0.086 -0.75 to 1.677 0.444
Patients treated with PI or NNRTI, n -0.295 -23.92 to 1.56 0.041
Lipodystrophy, n -0.202 -18.147 to 2.19 0.121
CD4+ T cell count, cells/mm 3 0.121 -0.005 to 0.19 0.260
Undetectable HIV-1 viral load a , n 0.053 -6.559 to 10.55 0.639
HDL-cholesterol, mmol/L 0.046 -12.89 to 17.55 0.759
Triglyceride, mmol/L 0.050 -2.45 to 3.49 0.726
Apolipoprotein A-I, g/L 0.230 -5.063 to 36.14 0.135
MCP-1, pg/mL 0.271 2.403 to 0.021 0.021
Insulin, pmol/L -0.009 -0.040 to 0.037 0.937
IL-8, ng/L 0.025 -0.012 to 0.016 0.828
hsCRP, mg/L -0.108 -1.00 to 0.328 0.312
Alanine aminotransferase, μKat/L 0.599 5.154 to 18.48 0.001
Aspartate aminotransferase, μKat/L -0.073 -9.98 to 6.36 0.668
  1. Dependent variable: FASN concentration (μg/L)
  2. BMI: body-mass index; NNRTI: non-nucleoside analogues reverse transcriptase inhibitors; PI: protease inhibitors, hsCRP: high sensitive C-reactive protein.
  3. aLimit of detection was 40 copies/mL