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Table 3 The expression of pGSK-3βTyr216 in relation to the expression of other tumor suppressor genes

From: Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

  Active GSK-3β
Positive (%)
Active GSK-3β
Negative (%)
Pvalue
APC    
   Positive 102 (52) 94 (48) 0.002*
   Negative 21 (30) 48 (70)  
PTEN    
   Positive 105 (51) 103 (50) 0.006*
   Negative 17 (30) 40 (70)  
MGMT    
   Positive 116 (50) 114 (50) < 0.001*
   Negative 10 (25) 30 (75)  
SMAD4    
   Positive 117 (49) 121 (51) 0.001*
   Negative 7 (19) 30 (81)  
KAI1    
   Positive 109 (52) 99 (48) < 0.001*
   Negative 17 (27) 47 (73)  
pVHL    
   Positive 118 (47) 131 (53) 0.091
   Negative 7 (28) 18 (72)  
FHIT    
   Positive 62 (48) 68 (52) 0.387
   Negative 56 (42) 77 (58)  
  1. APC: adenomatous polyposis coli; PTEN: phosphatase and tensin homologue deleted on chromosome 10; MGMT: O 6-methylguanine DNA-methyltransferase; KAI1: kangai 1; pVHL: von Hippel Lindau protein; FHIT: fragile histidine triad.
  2. * Considered to be statistically significant (< 0.05)