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Table 3 The expression of pGSK-3βTyr216 in relation to the expression of other tumor suppressor genes

From: Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

 

Active GSK-3β

Positive (%)

Active GSK-3β

Negative (%)

Pvalue

APC

   

   Positive

102 (52)

94 (48)

0.002*

   Negative

21 (30)

48 (70)

 

PTEN

   

   Positive

105 (51)

103 (50)

0.006*

   Negative

17 (30)

40 (70)

 

MGMT

   

   Positive

116 (50)

114 (50)

< 0.001*

   Negative

10 (25)

30 (75)

 

SMAD4

   

   Positive

117 (49)

121 (51)

0.001*

   Negative

7 (19)

30 (81)

 

KAI1

   

   Positive

109 (52)

99 (48)

< 0.001*

   Negative

17 (27)

47 (73)

 

pVHL

   

   Positive

118 (47)

131 (53)

0.091

   Negative

7 (28)

18 (72)

 

FHIT

   

   Positive

62 (48)

68 (52)

0.387

   Negative

56 (42)

77 (58)

 
  1. APC: adenomatous polyposis coli; PTEN: phosphatase and tensin homologue deleted on chromosome 10; MGMT: O 6-methylguanine DNA-methyltransferase; KAI1: kangai 1; pVHL: von Hippel Lindau protein; FHIT: fragile histidine triad.
  2. * Considered to be statistically significant (< 0.05)
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BMC Gastroenterology

ISSN: 1471-230X

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