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Table 2 The expression of pGSK-3βTyr216 in relation to that of cell cycle-regulatory proteins

From: Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

 

Active GSK-3β

Positive (%)

Active GSK-3β

Negative (%)

Pvalue

p16

   

   Positive

99 (54)

84 (46)

< 0.001*

   Negative

24 (28)

63 (72)

 

p21

   

   Positive

38 (26)

39 (74)

< 0.001*

   Negative

23 (12)

162 (88)

 

p27

   

   Positive

23 (59)

38 (41)

0.001*

   Negative

30 (3)

149 (97)

 

p53

   

   Positive

56 (55)

45 (45)

0.013*

   Negative

69 (40)

104 (60)

 

pRb

   

   Positive

118 (45)

142 (55)

0.208

   Negative

6 (67)

3 (33)

 

Cyclin D1

   

   Positive

28 (53)

25 (47)

0.202

   Negative

90 (43)

119 (57)

 
  1. pRb: phospho-retinoblastoma protein.
  2. * Considered to be statistically significant (< 0.05).