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Figure 7 | BMC Gastroenterology

Figure 7

From: Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice

Figure 7

Rates of apoptosis and necrosis of control group (A), of 70 ug/mL of nelfinavir (B), 100 ug/mL of indinavir (C), zidovudine (D) and didanosine (E) on intestinal epithelial IEC-6 cell apoptosis and necrosis after 24 h of exposure. Cells were stained with FITC-conjugated annexin V and propidium iodide and analyzed by flow cytometry. Results are shown as density plots with propidium iodide vs. annexin V-FITC. Viable cells have low annexin-V-FITC and low propidium iodide staining (lower-left quadrant), apoptotic cells have high annexin V-FITC and low propidium iodide staining (lower-right quadrant), and necrotic cells have high propidium iodide and annexin V-FITC staining (upper-right quadrant).

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