Intestinal transport of fluid and electrolytes (mEq/min/g) in experimental mice (n = at least 5 per group) after 7 days of treatment with either nelfinavir (NFV, 100 mg/kg), indinavir (IDV, 100 mg/kg), zidovudine (AZT, 50 mg/kg) and didanosine (DDI, 100 mg/kg) or PBS. Mice undergoing protease and reverse transcriptase inhibitors were submitted to intestinal perfusion (60 min) with ringer lactate. The results are expressed as mean ± SEM of at least 5 mice per group. *statistical significance (P < 0.05) compared to the PBS control group by ANOVA, Bonferroni's multiple test. A: sodium; B: chloride and C: fluid transport.