Increased area of necrotic damage in GC-C null mice. H&E stained liver sections were evaluated by morphometric image analysis to determine the extent of necrotic area. While the range overlaps, GC-C KO mice exhibited more necrotic liver damage at both 2 days (A) and 3 days (B) after CCl4 injection (*P = 0.04, N = 4-8 mice per genotype). Data is presented as the mean percentage necrosis in 3 fields (100×) per mouse. The bar is drawn at the median value for all groups.