Figure 2From: Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease Age of disease onset in Wilson disease patients grouped according to their type of ATP7B mutation. Analysis of Wilson disease (WD) patients possessing either (1) two 'severe' mutations (SM/SM); (2) one 'severe' mutation and one missense mutation (SM/MM), or (3) two missense mutations (MM/MM). Distribution of data presented as box and whisker plots: 25th percentile, median, 75th percentile, maximum, outliers (circles), and extreme values (x). Both assays resulted in no indeterminate results or missing data. a, difference for the comparison with SM/MM patients; b, difference for the comparison with MM/MM patients. Age of onset is significantly earlier in SM/SM patients (13 years; IQR, 9 - 13) compared to SM/MM patients (16 years; IQR, 14 - 18) and MM/MM patients (22 years; IQR, 14 - 27).Back to article page