Table 1 Characteristics of included trials
From: Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
Author/(year) | Design | Inclusion criteria | Treatment | No. of patients | M/F | Mean age (years) | Mean tumor size(cm) | Mean AFP (ng/ml) | Child-Pugh A/B | Mean follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|
Vivarelli | NRCT | (1)cirrhosis; (2)Child-Pugh class A or B | RFA | 79 | 67/12 | 67.8 ± 8.7 | -- | > 20 (n = 26) | 43/36 | 15.6 ± 11.7 |
(2004) | HR | 79 | 57/22 | 65.2 ± 8.2 | -- | > 20 (n = 43) | 70/9 | 28.9 ± 17.9 | ||
Hong | NRCT | (1) patients with liver cirrhosis whose Child-Pugh score is 5 or those without cirrhosis; (2)solitary tumor < 4 cm; (3) no vascular invasion; (4) no previous treatment | RFA | 55 | 41/14 | 59.1 ± 9.6 | 2.4 ± 0.6 | 447.3 ± 981.3 | 55/0 | 22.7* |
(2005) | HR | 93 | 69/24 | 49.2 ± 9.9 | 2.5 ± 0.8 | 644.0 ± 1745.6 | 93/0 | 25.5 | ||
Cho | NRCT | (1)Single or multiple (≤ 3 nodules) ≤ 5 cm; (2) Pugh-Child Class A; (3) no extrahepatic metastasis | RFA | 99 | 76/23 | 58 | 3.1 ± 0.8 | -- | 99/0 | 23 ± 9.4 |
(2005) | HR | 61 | 48/13 | 57 | 3.4 ± 1 | -- | 61/0 | 21.9 ± 9 .8 | ||
Montorsi | NRCT | (1) Cirrhosis (2)Solitary tumor ≤ 5 cm. single lesion; (3) Child A-B class; (4) segmental or subsegmental resection possible; (5) no previous treatment | RFA | 58 | 43/15 | 67 ± 6 | -- | 377.7 ± 1051.8 | 40/18 | 25.7 ± 16.7 |
(2005) | HR | 40 | 33/7 | 67 ± 9 | -- | 361.3 ± 1026.2 | 32/8 | 22.4 ± 17.5 | ||
Chen | RCT | (1) age 18 to 75 years; (2) solitary tumor ≤ 5 cm; (3)no extrahepatic metastasis; (4) Pugh-Child Class A, with no history of ncephalopathy, ascites refractory to diuretics, or variceal bleeding; (5) ICG-R15 < 30%; (6) no previous treatment | RFA | 71 | 56/15 | 51.9 ± 11.2 | -- | > 200 (n = 31) | 71/0 | 27.9 ± 10.6 |
(2006) | HR | 90 | 75/15 | 49.4 ± 10.9 | -- | > 200 (n = 30) | 90/0 | 29.2 ± 11.9 | ||
Lupo | NRCT | (1)Single tumor 3-5 cm; (2) no previous treatment; (3) no extrahepatic metastasis; (4) Child-Pugh class A or B | RFA | 60 | 47/13 | 68 | 3.65* | > 200 (n = 3) | 44/16 | 27 ± 18.7 |
(2007) | HR | 42 | 33/9 | 67 | 4 | > 200 (n = 5) | 28/14 | 31.3 ± 24.3 | ||
Guglielmi | NRCT | (1)Cirrhosis; (2)Single or multiple (≤ 3 nodules) ≤ 6 cm; (3)Child-Pugh class A or B | RFA | 109 | 88/21 | -- | -- | > 200 (n = 43) | 64/45 | 23 |
(2008) | HR | 91 | 73/18 | -- | -- | > 200 (n = 34) | 69/22 | 32 | ||
Hiraoka | NRCT | (1)Single tumor ≤ 3 cm; | RFA | 105 | 76/29 | 69.4 ± 9.1 | 1.98 | 114.5 | 79/26 | 847$ |
(2008) | (2) Child-Pugh class A or B | HR | 59 | 44/15 | 62.4 ± 10.6 | 2.27 | 427.8 | 54/5 | 927 | |
Abu-Hila | NRCT | (1)Cirrhosis; | RFA | 34 | 27/7 | 65 | 3* | -- | 27/7 | 30* |
(2008) | (2)Single tumor 1-5 cm. | HR | 34 | 26/8 | 67 | 3.8 | -- | 25/9 | 43 | |
Santambrogio | NRCT | (1)Single tumor < 5 cm; (2)Child-Pugh class A | RFA | 74 | 59/15 | 68 ± 7 | 2.66 | 9 | 74/0 | 38.2 ± 28.4 |
(2009) | HR | 78 | 55/23 | 68 ± 8 | 2.91 | 8 | 78/0 | 36.2 ± 23.5 |