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Table 4 Effects of melatonin and omeprazole on patients with GERD group IV (n = 9)

From: The potential therapeutic effect of melatonin in gastro-esophageal reflux disease

  Pretreatment with melatonin and omeprazole 4 weeks Post treatment with melatonin and omeprazole Post 8 weeks treatment with melatonin and omeprazole
A) Symptoms:    
1-Heart burn:    
   Yes 8 1(87.5%) 0 (100%)
   Duration(months) 1.4 ± 0.4   
2-Epigastric pain:    
   Yes 6 1(83.3%) 0 (100%)
   ration(months) 1.3 ± 0.4   
B) LES Study:    
1-LES pressure(mmHg) 10.3 ± 1.68 14.5 ± 1.26a 20.5 ± 1.22ab
2-Residual pressure (mmHg) 0.012 ± 0.44 0.21 ± 0.016 0.33 ± 0.016a
3-Relaxation duration (seconds) 6.8 ± 0.16 5.8 ± 0.13a 5.2 ± 0.12a
4-Relaxation % 85 ± 1.58 90 ± 1.23a 100 ± 0.00ab
C) PH (at 5 cm above the LES): 1.98 ± 0.37 6.1 ± 0.55a 7.5 ± 0.31ab
D) BAO (mmol/h) 24.9 ± 0.7 15.8 ± 0.9a 10.2 ± 0.9ab
E) Serum Gastrin (pg/ml) 21.9 ± 4.7 33.6 ± 2.7a 36.8 ± 2.1ab
D) Melatonin level at day time (pg/ml): 18.3 ± 3.8 28.83 ± 1.82a 34.5 ± 2.35ab
  1. a: p < 0.05 relative to pretreatment with melatonin
  2. b: p < 0.05 relative to 4 weeks Post treatment with melatonin