From: The potential therapeutic effect of melatonin in gastro-esophageal reflux disease
 | Pretreatment with melatonin and omeprazole | 4 weeks Post treatment with melatonin and omeprazole | Post 8 weeks treatment with melatonin and omeprazole |
---|---|---|---|
A) Symptoms: | Â | Â | Â |
1-Heart burn: | Â | Â | Â |
   Yes | 8 | 1(87.5%) | 0 (100%) |
   Duration(months) | 1.4 ± 0.4 |  |  |
2-Epigastric pain: | Â | Â | Â |
   Yes | 6 | 1(83.3%) | 0 (100%) |
   ration(months) | 1.3 ± 0.4 |  |  |
B) LES Study: | Â | Â | Â |
1-LES pressure(mmHg) | 10.3 ± 1.68 | 14.5 ± 1.26a | 20.5 ± 1.22ab |
2-Residual pressure (mmHg) | 0.012 ± 0.44 | 0.21 ± 0.016 | 0.33 ± 0.016a |
3-Relaxation duration (seconds) | 6.8 ± 0.16 | 5.8 ± 0.13a | 5.2 ± 0.12a |
4-Relaxation % | 85 ± 1.58 | 90 ± 1.23a | 100 ± 0.00ab |
C) PH (at 5 cm above the LES): | 1.98 ± 0.37 | 6.1 ± 0.55a | 7.5 ± 0.31ab |
D) BAO (mmol/h) | 24.9 ± 0.7 | 15.8 ± 0.9a | 10.2 ± 0.9ab |
E) Serum Gastrin (pg/ml) | 21.9 ± 4.7 | 33.6 ± 2.7a | 36.8 ± 2.1ab |
D) Melatonin level at day time (pg/ml): | 18.3 ± 3.8 | 28.83 ± 1.82a | 34.5 ± 2.35ab |