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Table 3 Effects of omeprazole on patients with GERD Group III (n = 9)

From: The potential therapeutic effect of melatonin in gastro-esophageal reflux disease

  Pretreatment with omeprazole 4 weeks Post treatment with omeprazole 8 weeks Post treatment with omeprazole
   A) Symptoms:    
1-Heart burn:    
   Yes 7 2 (71.4%) 0 (100%)
   Duration(months) 1.2 ± 0.3   
2-Epigastric pain:    
   Yes 6 2 0
   Duration(months) 1.3 ± 0.4 (66.7%) (100%)
   B)LES Study:    
1-LES pressure(mmHg) 10.5 ± 2.86 10.4 ± 4.05 10.5 ± 2.85
2-Residual pressure (mmHg) 0.1 ± 0.064 0.2 ± 0.15 0.1 ± 0.07
3-Relaxation duration (seconds) 6.5 ± 2.74 6.3 ± 2.7 6.3 ± 2.65
4-Relaxation % 87.2 ± 0.17 87.3 ± 0.25 87.1 ± 0.1
C) PH (at 5 cm above the LES): 2.1 ± 0.38 5.9 ± 0.48a 7.2 ± 0.32ab
D) BAO (mmol/h) 25.1 ± 0.6 17.2 ± 0.7a 11.5 ± 0.6ab
E) Serum Gastrin (pg/ml) 21.5 ± 4.6 32.1 ± 2.1a 35.9 ± 1.8ab
D) Melatonin level at day time (pg/ml): 18.5 ± 3.75 19.2 ± 3.47 17.9 ± 3.72
  1. a: p < 0.05 relative to pretreatment with melatonin
  2. b: p < 0.05 relative to 4 weeks Post treatment with melatonin