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Table 1 Comparison of control subjects and patients pretreated with melatonin, omeprazole and both (n = 9)

From: The potential therapeutic effect of melatonin in gastro-esophageal reflux disease

  control Pretreatment with melatonin Pretreatment with omeprazole Pretreatment with melatonin and omeprazole
   Symptoms:     
1-Heart burn:     
Yes 0 7 7 8
Duration(months)   1.3 ± 0.4 1.2 ± 0.3 1.4 ± 0.4
2-Epigastric pain:     
Yes 0 6 6 6
Duration(months)   1.4 ± 0.5 1.3 ± 0.4 1.3 ± 0.4
   A)LES Study:     
1-LES pressure(mmHg) 22.8 ± 1.3 10 ± 1.58a 10.5 ± 2.86a 10.3 ± 1.68a
2-Residual pressure (mmHg) 0.4 ± 0.01 0.012 ± 0.52a 0.1 ± 0.064a 0.012 ± 0.44a
3-Relaxation duration (seconds) 5.0 ± 0.1 6.8 ± 0.12a 6.5 ± 2.74a 6.8 ± 0.16a
4-Relaxation % 100 ± 0.00 86 ± 0.87a 87.2 ± 0.17a 85 ± 1.58a
C) PH (at 5 cm above the LES): 7.8 ± 0.4 2.3 ± 0.36a 2.1 ± 0.38a 1.98 ± 0.37a
D) BAO (mmol/h) 2.6 ± 0.6 24.7 ± 0.5a 25.1 ± 0.6a 24.9 ± 0.7a
E) Serum Gastrin(pg/ml) 41.8 ± 7.1 22.1 ± 4.2a 21.5 ± 4.6a 21.9 ± 4.7a
D) Melatonin level at day time (pg/ml): 36.1 ± 2.3 18.2 ± 5.54a 18.5 ± 3.75a 18.3 ± 3.8a
  1. a: p < 0.05 relative to control