Figure 4
From: The Role of T cell PPAR γ in mice with experimental inflammatory bowel disease
Effect of T cell-specific PPAR γ deletion on leukocyte extravasation markers. WT or CD4cre mice were treated with 2.5% dextran sodium sulfate (DSS) for 7 days, and microarray analyses was performed. Colons of WT (A) and CD4cre (B) mice were assessed for leukocyte extravasation markers integrin alpha V (intgav), integrin alpha X (intgax), integrin beta 2 (intgb2), intracellular adhesion molecule 1 (ICAM-1), mucosal addressin adhesion molecule 1 (MAdCAM-1), vascular adhesion molecule 1 (VCAM-1) and P-selectin. Results from microarray were validated with real time PCR. Points with an asterisk are significantly different from the day 0 time point (P < 0.05). Points with a double asterisk also indicate a significant difference due to genotype at a given time point (P < 0.05).