Effect of T cell-specific PPAR γ deletion on colon histopathology. WT or CD4cre mice were treated with 2.5% dextran sodium sulfate (DSS) or water (no DSS) for 7 days. Representative photomicrographs (40 ×) from wt, no-DSS (A), wt, DSS (B), CD4cre, no-DSS (C), and CD4cre, DSS (D) groups are depicted. All specimens underwent blinded histological examination and were scored (1-4) on epithelial erosion (E), leukocyte infiltration (F), and mucosal wall thickening (G) on days 0, 2, and 7 of DSS challenge. Data are represented as mean ± standard error. Points with an asterisk are significantly different at a given time point (P < 0.05).