Figure 3

Regression of fibrosis monitored by histological analysis (Top) and by the non-invasive index (Bottom). The degree of fibrosis was evaluated by both the stage and inflammatory grade according to METAVIR system. (Stars): refers to significant changes between the corresponding groups versus group II, (Hearts) refers to significant changes between the corresponding groups versus group V, and (Black squires): refers to significant changes between the corresponding groups versus group X. Also, 4 serum (non-invasive) markers were combined in a logarithmic formula and used to scale the degree of fibrosis in mice of different groups. The scale ranges from 0 (corresponding to normal liver) up to 2 (corresponding to invasive fibrosis). The bottom panel presents the index values of different test groups