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Figure 5 | BMC Gastroenterology

Figure 5

From: Antibodies against gonadotropin-releasing hormone (GnRH) and destruction of enteric neurons in 3 patients suffering from gastrointestinal dysfunction

Figure 5

Details of a myenteric ganglion and surrounding muscle tissue. 5A. The cytoplasm of the enlarged neuron is filled with small tightly packed eosinophilic granules, the nucleus is compressed, elongated (large arrow). There are two other neurons with vacuolized cytoplasm (double arrows) and another small, shrunken neuron (short arrow) (Haematoxylin & eosin;bar: 20 μm). 5B. Eosinophilic residual body with shadows of vacuoles of a necrotic neuron (large arrow). The double arrows show a degenerating neuron containing very large nucleolus and extremely pale cytoplasm with a few perinuclear vacuoles. (Haematoxylin & eosin; bar: 20 μm). 5C. Ten μm large, activated T-lymphocytes in the vicinity of two neurons (arrows). (CD3 immunohistochemistry; bar: 20 μm). 5D and E show detail of the circular muscle with a small nerve as followed up on serial sections. 5D. There is a small cell containing a densely stained rounded nucleus (arrow) along the small nerve. (Neurofilament immunohistochemistry; bar: 20 μm). 5E. Several CD3+ T-lymphocytes are seen along the nerve shown on 5D. (CD3 immunohistochemistry; bar: 20 μm).

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