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Figure 4 | BMC Gastroenterology

Figure 4

From: Antibodies against gonadotropin-releasing hormone (GnRH) and destruction of enteric neurons in 3 patients suffering from gastrointestinal dysfunction

Figure 4

Neuronal survival of neurons pre-cultured for 4 days followed by 2 days of culture in the presence of (A) serum from case 3 (n = 5), (B) serum from case 1 (n = 8), (C) serum from case 2 (n = 3), (D) serum from healthy blood donors (n = 8), (E) gonadotropin-releasing hormone (GnRH) antibodies raised in rabbit (n = 6-7) and (F) buserelin (n = 8). Addition of sera from cases number one and two, from healthy blood donors or GnRH antibodies caused no change in neuronal survival while serum from case 3 significantly and concentration-dependently reduced neuronal survival. Buserelin markedly enhanced neuronal survival in a concentration-dependent manner. *** p < 0.01, as compared to the controls run in parallel.

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