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Table 2 The sensitivity/specificity of each tumor marker for HCC was depicted.

From: A novel biomarker TERTmRNA is applicable for early detection of hepatoma

 

Sensitivity

Specificity

OR

PPV/NPV

Cut-off point

hTERTmRNA

90.2

85.4

19.0

83.0/85.9

3. 97 (logarithmic copy number)

AFP

76.6

66.2

11.1

74.6/67.7

<10 (ng/ml)

AFP-L3

60.5

88.7

2.2

59.6/92.2

<10 (%)

DCP

83.4

80.3

7.6

78.4/73.5

<40 (mAU/ml)

  1. The sensitivity/specificity values are 90.2%/85.4% for hTERTmRNA, 76.6%/66.2% for AFP, 60.5%/88.7% for AFP-L3, and 83.4%/80.3% for DCP. Regarding a diagnostic assessment in sensitivity and specificity, hTERTmRNA is identified as the most excellent tumor marker. OR: odds ratio, PPV: positive predictive value (%), NPV: negative predictive value (%).