CORM-2 modulates pro- and anti-apoptotic proteins and decreases neutrophil infiltration. A Western blot analysis of the expression of ICAM-1, caspase-3, Bcl-2 and HO-1 in sham-operated, I/Ri operated, CORM-2 treated and iCORM-2 treated rats. B The relative expression levels of ICAM-1 and caspase-3 or C Bcl-2 and HO-1 were analysed with densitometry analysis in relation to β-actin. D Serum levels of TNF-α and E IL-6 of rats subjected to 60 min. of ischemia followed by 6 h of reperfusion. F Liver tissue MPO activity for each group was determined. *P < 0.05 vs. I/R group.