Strategy | Number subjects | Presumed fibrosis | Confirmed fibrosis |
---|---|---|---|
Prevalence fibrosis 1 | 7463 | 209 (2.8%) | 50 (0.7-1.4%) |
Metabolic factors oriented | |||
Predictive value | |||
At least one metabolic factor | 3990 | 163 (4.1%) | 40 (1.0%) |
None | 3473 | 46 (1.3%) | 10 (0.3%) |
Odds ratio | 7463 | 3.2 (2.3-4.5) | 3.4 (1.7-7.5) |
Area under ROC curve | 4854 | 0.69(0.64-0.73) | 0.71 (0.59-0.80) |
Alcohol-oriented per self- | |||
reported consumption | |||
Predictive value | |||
>10 g female/20 g male | 1686 | 52 (3.1%) | 15 (0.9%) |
<= 10 g female/<= 20 g male | 5770 | 157 (2.7%) | 35 (0.6%) |
Odds Ratio | 7456 | 1.1 (0.8-1.6) | 1.5 (0.8-2.8) |
Area under ROC curve | 7456 | 0.55(0.51-0.59) | 0.52 (0.43-0.60) |
CDT oriented | |||
Predictive value | |||
CDT>1.6 | 348 | 45 (12.9%) | 22 (6.3%) |
CDT<= 1.6 | 749 | 29 (3.9%) | 8 (1.1%) |
Odds Ratio | 1097 | 3.7 (2.2-6.2) | 6.1 (2.6-15.4) |
Area under ROC curve | 1097 | 0.72(0.64-0.78) | 0.75 (0.67-0.86) |
Hepatitis Virus-oriented 2 | |||
Predictive value | |||
HBsAg or HCV antibody | 36 | 5 (13.9%) | 3 (8.3%) |
HBsAg and HCV negative or not done at baseline | 7427 | 204 (2.7%) | 47 (0.6%) |
Odds ratio | 7463 | 5.9 (1.9-15.6) | 15.3 (3.4-50.9) |
Transaminases- oriented | |||
Predictive value | |||
ALT >= 50 IU/L | 513 | 53 (10.3%) | 17 (3.3%) |
ALT < 50 IU/L | 6950 | 156 (2.2%) | 33 (0.5%) |
Odds ratio | 7463 | 5.0 (3.6-7.0) | 7.2 (3.8-13.4) |
Area under ROC curve | 7463 | 0.72(0.68-0.75) | 0.78 (0.72-0.83) |
Age-oriented | |||
Predictive value | |||
Age > 60 years | 2960 | 156 (5.3%) | 42 (1.4%) |
Age <= 60 years | 4503 | 53 (1.2%) | 8 (0.2%) |
Odds ratio | 7463 | 4.7 (3.4-6.5) | 8.3 (3.8-19.5) |
Area under ROC curve | 7463 | 0.75(0.72-0.78) | 0.79 (0.71-0.84) |
Gender-oriented | |||
Male | 4113 | 189 (4.6%) | 47 (1.1%) |
Female | 3350 | 20 (0.6%) | 3 (0.1%) |
Odds ratio | 7463 | 8.0 (5.0-13.1) | 12.0 (4.0-54.1) |