Figure 1

Exploratory analysis using three-dimensional plots of the percentages of genes status for individual cases is illustrated. Red square: Normal Mucosa; Green Square: Megaesophagus, A. EGFR, Mean frequency of loss in the CM = 6.84%, CM30 ~30% of loss; B. FHIT, Mean frequency of loss in the CM = 0.63%, CM36 ~10% of loss; C. PIK3CA, Mean frequency of loss: 23.63%, Mean frequency of gain: 0.92%, CM13 and CM19 ~40% of loss, CM28 and CM11, between 5 and 10% of gain; D. TP63, Mean frequency of loss = 23.29%, Mean frequency of gain = 1.07%, CM13 ~45% of loss, CM6 and CM7 ~10% of gain; E. CDKN2A, Mean frequency of loss = 4.76%, Mean frequency of gain = 1.79%, CM12 ~12% of loss, CM 11 and CM 16 ~6% of gain; F. MYC, Mean frequency of gain = 0.87%, CM3, CM6 and CM30 between 5 and 7.5% of gain.