Table 1 Daily symptom scores and number of weeks with satisfactory relief of symptoms during the two treatment periods.
Symptoms | LpMF1298 | Placebo | Paired differences, mean (CI) | Statistics |
|---|---|---|---|---|
Number of weeks with satisfactory relief of symptoms | 0.50 (0.89) | 1.44 (1.26) | -0.94 (-1.57 to -0.31) | P = 0.006 |
Individual symptoms | ||||
Abdominal Pain/Discomfort | 1.55 (0.57) | 1.14 (0.55) | 0.41 (0.09 to 0.73) | P = 0.016 |
Stool frequency (normalised) | 0.15 (0.18) | 0.19 (0.21) | -0.03 (-0.14 to 0.07) | P = 0.48 |
Stool consistency (normalised) | 0.86 (0.55) | 0.61 (0.55) | 0.25 (-0.12 to 0.61) | P = 0.17 |
Urgency | 1.54 (0.59) | 1.12 (0.56) | 0.42 (0.17 to 0.66) | P = 0.002 |
Bloating | 1.23 (0.59) | 1.16 (0.68) | 0.07 (-0.31 to 0.46) | P = 0.69 |
Straining | 0.51 (0.37) | 0.58 (0.40) | -0.07 (-0.17 to 0.03) | P = 0.13 |
Incomplete bowel movement | 0.59 (0.35) | 0.54 (0.41) | 0.05 (-0.06 to 0.17) | P = 0.35 |
Sum symptoms | ||||
IBS sum score | 6.44 (1.81) | 5.35 (1.77) | 1.09 (0.31 to 1.87) | P = 0.010 |
Stool characteristics | ||||
Stool frequency | 1.52 (0.68) | 1.33 (0.58) | 0.19 (-0.07 to 0.45) | P = 0.15 |
Stool consistency | 4.84 (1.51) | 4.17 (1.31) | 0.67 (0.20 to 1.13) | P = 0.008 |
Diarrhoea (consistency + frequency) | 6.36 (1.99) | 5.50 (1.71) | 0.86 (0.33 to 1.39) | P = 0.004 |