Figure 6

Age-related CRC-446 positivity and CRC incidence rates. Percent of SDCL control subjects by decade of life with CRC-446 levels less than 0.23 ug/ml CAE (squares, primary y-axis). Linear regression analysis (based on the median age of each decade of life for the SDCL group) was used to determine the equation y = 0.65x-15.8, representing a .65% annual probability of a positive test result (concentration less than 0.23 ug/ml CAE) given a prior negative test (concentration greater than 0.23 ug/ml CAE). For comparison, the incidence rate of CRC as a percent of each age group (based on Canadian Cancer Statistics, 2009), is shown (circles, secondary axis).